Nagai Takashi, Tomita Kazunari, Kubo Kazutoshi, Ikeda Jun, Kawasaki Keikichi, Inagaki Katsunori
Department of Rehabilitation Medicine, Showa University School of Medicine, Tokyo, Japan; Department of Orthopedic Surgery, Showa University School of Medicine, Tokyo, Japan.
Department of Orthopedic Surgery, Showa University School of Medicine, Tokyo, Japan.
Int J Surg Case Rep. 2023 Apr;105:108056. doi: 10.1016/j.ijscr.2023.108056. Epub 2023 Mar 27.
Although corticosteroids are effective for bronchial asthma, they are associated with various side effects, such as osteonecrosis of the femoral head and tibial condyle and osteoporosis. Here, we report a patient who was on corticosteroids for a long period of time due to severe asthma, which was thought to have led to lunate osteonecrosis of both wrist joints. Calcitonin (elcatonin), an osteoporosis drug, was administered to the wrist joint.
Allergy to anesthetics and various non-steroidal anti-inflammatory drugs (NSAIDs) made surgical treatment not possible and pain control difficult. In addition, pain in the wrist joint interfered with activities of daily living (ADLs). When calcitonin was administered intra-articularly into the wrist joint, the pain in the wrist joint was relieved and ADLs were improved. However, the pain-suppressing effect lasted only 1 week, and pain returned to the original state by the second week after treatment. Repeated injections were necessary every 2 weeks.
This is the first report of the effectiveness of intra-articular calcitonin in a patient with osteonecrosis of the lunate. This treatment may be applicable to patients with allergies to anesthesia and NSAIDs.
In the present case, calcitonin administered intra-articularly to the wrist appeared to be effective in pain control for steroid-induced lunate osteonecrosis.
尽管皮质类固醇对支气管哮喘有效,但它们会引发各种副作用,如股骨头和胫骨髁的骨坏死以及骨质疏松症。在此,我们报告一名因严重哮喘长期使用皮质类固醇的患者,据认为这导致了双侧腕关节月骨坏死。向腕关节施用了一种骨质疏松症药物降钙素(依降钙素)。
对麻醉剂和各种非甾体抗炎药(NSAIDs)过敏使得手术治疗无法进行且疼痛控制困难。此外,腕关节疼痛干扰了日常生活活动(ADL)。当向腕关节关节腔内注射降钙素时,腕关节疼痛得到缓解且ADL得到改善。然而,疼痛抑制效果仅持续1周,治疗后第二周疼痛恢复到原来状态。每2周需要重复注射。
这是关节腔内注射降钙素对月骨坏死患者有效性的首次报告。这种治疗可能适用于对麻醉和NSAIDs过敏的患者。
在本病例中,向腕关节关节腔内注射降钙素似乎对类固醇诱导的月骨坏死的疼痛控制有效。