Monaco J J, McDevitt H O
Hum Immunol. 1986 Apr;15(4):416-26. doi: 10.1016/0198-8859(86)90019-4.
In addition to encoding the well-known class I (H-2), II (Ia), and III (complement components C2, C4, and factor B) antigens, the murine MHC controls the expression of a large, intracellular protein complex of unknown function. This complex is composed of a large number of noncovalently linked low molecular weight polypeptide subunits (hence the name, LMP) which are biochemically, serologically, and genetically distinct from class I, II, and III antigens. Only two of these subunits display electrophoretic polymorphism within the standard inbred mouse strains, and both of these polymorphisms map within the H-2 complex, between the H-2K and I-A subregions. The remainder of the LMP complex subunits have not been mapped, and may be encoded elsewhere in the genome. A biochemically similar complex has been detected in human cells, although linkage to HLA remains to be established. In this article we will review the biochemistry, serology, and genetics of the LMP antigens, and will speculate on their biological function.
除了编码著名的I类（H-2）、II类（Ia）和III类（补体成分C2、C4和B因子）抗原外，小鼠主要组织相容性复合体（MHC）还控制着一种功能未知的大型细胞内蛋白质复合体的表达。该复合体由大量非共价连接的低分子量多肽亚基组成（因此得名，低分子量多肽，LMP），这些亚基在生化、血清学和遗传学上与I类、II类和III类抗原不同。在标准近交系小鼠品系中，这些亚基中只有两个表现出电泳多态性，并且这两种多态性都定位在H-2复合体内，位于H-2K和I-A亚区域之间。LMP复合亚基的其余部分尚未定位，可能由基因组中的其他位置编码。在人类细胞中也检测到了一种生化性质相似的复合体，尽管与人类白细胞抗原（HLA）的连锁关系尚待确定。在本文中，我们将综述LMP抗原的生物化学、血清学和遗传学，并推测它们的生物学功能。
