Montgomery Blair High School, 51 University Blvd E, Silver Spring, MD 20901, USA.
ABP Biosciences, 405 E Gude Dr, Rockville, MD 20850, USA.
Bioorg Med Chem Lett. 2023 May 1;87:129262. doi: 10.1016/j.bmcl.2023.129262. Epub 2023 Mar 29.
A new hydrocyanine probe containing a ROS-responsive element and a mitochondrial-targeting moiety, as well as a thiol-reactive chloromethyl group, has been designed for imaging reactive oxygen species (ROS) in the mitochondria of live cells. This hydrocyanine probe is cell-permeable, selectively targets mitochondria and responds to superoxide and hydroxyl radical, and can be used for detection of ROS production in the mitochondria of live cells caused by an oxidative stress.
一种新的氢氰酸探针，包含一个 ROS 响应元件和一个靶向线粒体的部分，以及一个硫醇反应性氯甲基基团，被设计用于在活细胞的线粒体中成像活性氧（ROS）。这种氢氰酸探针具有细胞通透性，选择性地靶向线粒体，并对超氧自由基和羟基自由基作出响应，可用于检测由氧化应激引起的活细胞线粒体中 ROS 的产生。
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