O'Brien S E, Roth J A, Hill B L
J Am Vet Med Assoc. 1986 Apr 1;188(7):699-701.
Twenty-eight pups from a general pet population were vaccinated for canine parvovirus (CPV) with a combination vaccine every 3 weeks until the pups were 11 to 16 weeks old. Canine parvovirus antibody titers were measured by serum neutralization before each vaccination and greater than or equal to 2 weeks after the final vaccination. Eighteen pups that initially were seronegative for CPV seroconverted after 1 to 3 doses of modified-live virus CPV vaccine administered when the pups were between 8 and 16 weeks old; 16 of 18 seroconverted after the 1st dose. Of 10 pups that were seropositive for CPV at initial examination, 7 did not develop protective titers after 3 doses of vaccine, with the last dose given when the pups were 14 to 16 weeks old. Maternally derived antibody was the primary cause of vaccination failure.
从普通宠物群体中选取28只幼犬，每3周用联合疫苗接种犬细小病毒（CPV），直至幼犬11至16周龄。在每次接种前以及最后一次接种后大于或等于2周时，通过血清中和法测量犬细小病毒抗体滴度。18只最初对CPV血清学阴性的幼犬在8至16周龄时接种1至3剂改良活病毒CPV疫苗后发生血清转化；18只中有16只在第1剂后发生血清转化。在初次检查时对CPV血清学阳性的10只幼犬中，7只在接种3剂疫苗后未产生保护性滴度，最后一剂接种时幼犬为14至16周龄。母源抗体是疫苗接种失败的主要原因。
