苄星青霉素所致中性粒细胞减少症。
Benzylpenicillin-induced neutropenia.
作者信息
Al-Hadramy M S, Aman H, Omer A, Khan M A
出版信息
J Antimicrob Chemother. 1986 Feb;17(2):251-3. doi: 10.1093/jac/17.2.251.
PMID:3700289
Abstract
Neutropenia is a potentially serious complication of parenteral benzylpenicillin administration. It is thought to occur more frequently in patients receiving infusions of stored penicillin solutions. We report three cases of neutropenia produced after bolus injections of freshly prepared benzylpenicillin. Twenty-five other cases were reviewed from the literature and the data summarized.
摘要
中性粒细胞减少是胃肠外给予苄青霉素的一种潜在严重并发症。据认为，在接受储存青霉素溶液输注的患者中更常发生。我们报告了3例静脉推注新鲜配制的苄青霉素后发生中性粒细胞减少的病例。并从文献中回顾了其他25例病例并总结了数据。
相似文献
1
Benzylpenicillin-induced neutropenia.苄星青霉素所致中性粒细胞减少症。
J Antimicrob Chemother. 1986 Feb;17(2):251-3. doi: 10.1093/jac/17.2.251.
2
Profound neutropenia associated with benzylpenicillin.
South Med J. 1983 Oct;76(10):1299-302. doi: 10.1097/00007611-198310000-00026.
3
[Neutropenia induced by penicillin].
Rev Med Chil. 1987 Mar;115(3):239-40.
4
Gonococcal endocarditis with penicillin-induced bone marrow hypoplasia. Role of echocardiography.
JAMA. 1981 Aug 7;246(6):672-3.
5
A prospective study of neutropenia induced by high doses of beta-lactam antibiotics.高剂量β-内酰胺类抗生素所致中性粒细胞减少症的前瞻性研究。
J Antimicrob Chemother. 1990 Mar;25(3):449-53. doi: 10.1093/jac/25.3.449.
6
Penicillin-induced agranulocytosis.
West J Med. 1988 Oct;149(4):460-2.
7
Neutropenia after penicillins: toxic or immune-mediated?青霉素治疗后出现的中性粒细胞减少：是毒性反应还是免疫介导反应？
Klin Wochenschr. 1981 Aug 17;59(16):877-88. doi: 10.1007/BF01721921.
8
[Neutropenia caused by penicillin].
Rev Clin Esp. 1986 Jun;179(2):105-6.
9
[Neutropenia caused by penicillin].
Med Clin (Barc). 1984 May 5;82(17):779.
10
Neutropenia induced by high-dose intravenous benzylpenicillin in treating neurosyphilis: Does it really matter?大剂量静脉注射苄星青霉素治疗神经梅毒所致中性粒细胞减少症：真的有关系吗？
PLoS Negl Trop Dis. 2017 Mar 13;11(3):e0005456. doi: 10.1371/journal.pntd.0005456. eCollection 2017 Mar.
引用本文的文献
1
High-Dose Benzylpenicillin Treatment-Induced Febrile Neutropenia in HIV-Infected Male with Neurosyphilis: Case Report.大剂量苄星青霉素治疗致HIV感染合并神经梅毒男性患者发热性中性粒细胞减少症：病例报告
Antibiotics (Basel). 2025 May 30;14(6):560. doi: 10.3390/antibiotics14060560.
2
Beta-Lactam Dose Optimisation in the Intensive Care Unit: Targets, Therapeutic Drug Monitoring and Toxicity.重症监护病房中β-内酰胺类药物剂量优化：目标、治疗药物监测与毒性
Antibiotics (Basel). 2023 May 8;12(5):870. doi: 10.3390/antibiotics12050870.
3
Neutropenia induced by high-dose intravenous benzylpenicillin in treating neurosyphilis: Does it really matter?大剂量静脉注射苄星青霉素治疗神经梅毒所致中性粒细胞减少症：真的有关系吗？
PLoS Negl Trop Dis. 2017 Mar 13;11(3):e0005456. doi: 10.1371/journal.pntd.0005456. eCollection 2017 Mar.
Zotero 插件