Ford Janet H, Lage Maureen J, Boye Kristina S, Bae Jay P, Terrell Kendra A, Bunck Mathijs C
Value, Evidence and Outcomes, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 36255, United States of America.
HealthMetrics Outcomes Research, 17 Benton's Knoll, Guilford, CT 06437, United States of America.
J Diabetes Complications. 2023 May;37(5):108454. doi: 10.1016/j.jdiacomp.2023.108454. Epub 2023 Mar 17.
This research examines the prevalence of morbidity and mortality among people with obesity with or without prediabetes.
This observational study uses Optum® Market Clarity deidentified data from 2007 to 2020. Individuals with obesity without prediabetes (obesity only) were matched 1:1 to adults with prediabetes plus obesity based upon age, sex, race, ethnicity, and region. Age and sex adjusted prevalence rates and 95 % CIs were calculated for morbidity and mortality for each 365-day period post index date and over the entire 5-year post-period.
After 5-years, the adjusted mortality rate was 10.1 % for adults with obesity plus prediabetes and 6.9 % for adults with obesity only (p < 0.05). Five years post index date, the prevalence of type 2 diabetes was 25.3 % for people with obesity plus prediabetes and 9.2 % for people with obesity only (p < 0.05). Prevalence rates after 5 years for atherosclerotic cardiovascular disease (13.1 % v 8.1 %), composite cardiovascular outcome (7.0 % v 4.4 %) and composite cardio-renal outcome (8.9 % v 5.0 %) were significantly higher for adults with obesity plus prediabetes compared to adults with obesity only (all p < 0.05).
Results of this study indicate that the presence of prediabetes contributes to the development of additional morbidity and mortality in adults with obesity.
本研究调查有或无糖尿病前期的肥胖人群的发病和死亡情况。
本观察性研究使用了2007年至2020年Optum®市场透明度匿名数据。无糖尿病前期的肥胖个体（仅肥胖）根据年龄、性别、种族、民族和地区与患有糖尿病前期加肥胖的成年人进行1:1匹配。计算指数日期后每365天期间以及整个5年后期的年龄和性别调整后的发病率和死亡率以及95%置信区间。
5年后，患有肥胖加糖尿病前期的成年人调整后的死亡率为10.1%，仅肥胖的成年人调整后的死亡率为6.9%（p<0.05）。指数日期后5年，肥胖加糖尿病前期人群的2型糖尿病患病率为25.3%，仅肥胖人群的患病率为9.2%（p<0.05）。与仅肥胖的成年人相比，肥胖加糖尿病前期的成年人5年后动脉粥样硬化性心血管疾病（13.1%对8.1%）、复合心血管结局（7.0%对4.4%）和复合心肾结局（8.9%对5.0%）的患病率显著更高（所有p<0.05）。
本研究结果表明，糖尿病前期的存在会导致肥胖成年人出现更多的发病和死亡情况。
