逆转录病毒反弹综合征的临床特征：一例病例报告及文献复习。

Clinical Characteristics of Retroviral Rebound Syndrome: A Case Report and Literature Review.

机构信息

Department of Infectious Diseases, Japanese Red Cross Medical Center, Japan.

Department of Pathology, Japanese Red Cross Medical Center, Japan.

出版信息

Intern Med. 2023;62(7):1089-1093. doi: 10.2169/internalmedicine.9661-22. Epub 2023 Apr 1.

DOI:10.2169/internalmedicine.9661-22

PMID:37005296

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10125823/

Abstract

We herein report a case of retroviral rebound syndrome (RRS) complicated with hemophagocytic lymphohistiocytosis. Owing to the paucity of comprehensive data on RRS, we also conducted a literature review. All 19 cases included in the review presented within 2 months after the discontinuation of antiretroviral therapy. They were usually accompanied by both a significant decrease in CD4 count (median 292/μL) and a rapid increase in plasma human immunodeficiency virus loads (median 3.5×10/mL). Although life-threatening complications were reported, the overall prognosis was favorable. The outcomes of this review aided in the diagnosis of the present case.

摘要

我们在此报告一例逆转录病毒反弹综合征（RRS）合并噬血细胞性淋巴组织细胞增生症。由于 RRS 的综合数据有限，我们还进行了文献复习。综述中纳入的 19 例病例均在停止抗逆转录病毒治疗后 2 个月内出现。它们通常伴有 CD4 计数显著下降（中位数 292/μL）和血浆人类免疫缺陷病毒载量快速增加（中位数 3.5×10/mL）。尽管有报道称存在危及生命的并发症，但总体预后良好。本综述的结果有助于该病例的诊断。