Liu Yuxing, Tan Jin, Miao Yuyang, Zhang Qiang
Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin Geriatrics Institute, Tianjin, China.
Curr Stem Cell Res Ther. 2024;19(1):63-70. doi: 10.2174/1574888X18666230330083206.
As a sleep breathing disorder, characterized by intermittent hypoxia (IH) and Obstructive sleep apnea (OSA), is believed to decrease the cognitive function of patients. Many factors are thought to be responsible for cognitive decline in OSA patients. Neurogenesis, a process by which neural stem cells (NSCs) differentiate into new neurons in the brain, is a major determinant affecting cognitive function. However, there is no clear relationship between IH or OSA and neurogenesis. In recent years, increasing numbers of studies on IH and neurogenesis are documented. Therefore, this review summarizes the effects of IH on neurogenesis; then discusses the influencing factors that may cause these effects and the potential signaling pathways that may exist. Finally, based on this impact, we discuss potential methods and future directions for improving cognition.
作为一种以间歇性缺氧（IH）和阻塞性睡眠呼吸暂停（OSA）为特征的睡眠呼吸障碍，被认为会降低患者的认知功能。许多因素被认为是导致OSA患者认知下降的原因。神经发生是神经干细胞（NSCs）在大脑中分化为新神经元的过程，是影响认知功能的主要决定因素。然而，IH或OSA与神经发生之间没有明确的关系。近年来，关于IH与神经发生的研究越来越多。因此，本综述总结了IH对神经发生的影响；然后讨论了可能导致这些影响的影响因素以及可能存在的潜在信号通路。最后，基于这种影响，我们讨论改善认知的潜在方法和未来方向。
