Goggiamani Antonella, Arcadi Antonio, Ciogli Alessia, De Angelis Martina, Dessalvi Stefano, Fabrizi Giancarlo, Iavarone Federica, Iazzetti Antonia, Sferrazza Alessio, Zoppoli Roberta
Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma P.le A. Moro 5 00185 Rome Italy
Dipartimento di Dipartimento di Scienze Fisiche e Chimiche, Università degli Studi di L'Aquila Via Vetoio 67100 Coppito (AQ) Italy
RSC Adv. 2023 Mar 29;13(15):10090-10096. doi: 10.1039/d3ra01335a. eCollection 2023 Mar 27.
The synthesis of 2,3-dihydropyrazino[1,2-]indol-4(1)-ones from the sequential reaction of amino acid methyl esters with readily available indole-2-ylmethyl acetates is described. The reaction proceeds under basic conditions of highly unstable and reactive 2-alkylideneindolenines followed by Michael-type addition of α-amino acid methyl esters/intramolecular cyclization.
描述了由氨基酸甲酯与易得的吲哚 - 2 - 基甲基乙酸酯的顺序反应合成2,3 - 二氢吡嗪并[1,2 - ]吲哚 - 4(1) - 酮。该反应在高度不稳定且具反应性的2 - 亚烷基吲哚啉的碱性条件下进行，随后是α - 氨基酸甲酯的迈克尔型加成/分子内环化。
