继发进展型多发性硬化的神经生理学和临床生物标志物：一项横断面研究。
Neurophysiological and clinical biomarkers of secondary progressive multiple sclerosis: A cross-sectional study.
作者信息
Tartaglia Matteo, Canevelli Marco, Malimpensa Leonardo, Belvisi Daniele, Baione Viola, Ferrazzano Gina, Leodori Giorgio, Berardelli Alfredo, Conte Antonella
机构信息
Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Department of Neurophysiology, IRCCS Neuromed, Pozzilli, Italy.
出版信息
Front Neurol. 2023 Mar 16;14:1138600. doi: 10.3389/fneur.2023.1138600. eCollection 2023.
Timely diagnosis of secondary progressive multiple sclerosis (SPMS) represents a clinical challenge. The Frailty Index, a quantitative frailty measure, and the Neurophysiological Index, a combined measure of sensorimotor cortex inhibitory mechanism parameters, have recently emerged as promising tools to support SPMS diagnosis. The aim of this study was to explore the possible relationship between these two indices in MS. MS participants underwent a clinical evaluation, Frailty Index administration, and neurophysiological assessment. Frailty and Neurophysiological Index scores were found to be higher in SPMS and correlated with each other, thus suggesting that they may capture similar SPMS-related pathophysiological mechanisms.
继发性进展型多发性硬化症（SPMS）的及时诊断是一项临床挑战。衰弱指数是一种定量的衰弱测量方法，神经生理指数是感觉运动皮层抑制机制参数的综合测量方法，最近已成为支持SPMS诊断的有前景的工具。本研究的目的是探讨这两个指数在多发性硬化症中的可能关系。多发性硬化症参与者接受了临床评估、衰弱指数测定和神经生理学评估。结果发现，SPMS患者的衰弱指数和神经生理指数得分更高，且两者相互关联，这表明它们可能捕捉到了与SPMS相关的相似病理生理机制。
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