Ozbek Merve, Pehlivanoglu Seren, Artunay Halil Ozgur
Department of Ophthalmology, Beyoglu Eye Training and Research Hospital, Istanbul, Turkey.
Oman J Ophthalmol. 2023 Feb 21;16(1):142-144. doi: 10.4103/ojo.ojo_9_22. eCollection 2023 Jan-Apr.
Bietti crystalline dystrophy is a rare hereditary autosomal recessive disease that causes photoreceptor loss secondary to degeneration of retinal pigment epithelium due to intracellular retinal pigment epithelial crystalline deposits and abnormal lipid metabolism. We aimed to present a case of choroidal neovascular membrane secondary to Bietti crystalline dystrophy diagnosed with multimodal imaging and treated with an intravitreal injection of aflibercept. A single dose of aflibercept injection might be effective due to its higher affinity for vascular endothelial growth factor (VEGF) in comparison with other anti-VEGFs. It might be a treatment alternative that can be considered in the choroidal neovascular membrane due to uncommon etiologies.
比埃蒂结晶状营养不良是一种罕见的常染色体隐性遗传性疾病，由于细胞内视网膜色素上皮结晶沉积和脂质代谢异常，导致视网膜色素上皮变性，继发光感受器丧失。我们旨在介绍一例继发于比埃蒂结晶状营养不良的脉络膜新生血管膜病例，该病例通过多模态成像诊断，并接受了玻璃体内注射阿柏西普治疗。与其他抗血管内皮生长因子（VEGF）药物相比，单剂量阿柏西普注射可能因其对VEGF具有更高的亲和力而有效。由于病因不常见，它可能是一种可考虑用于治疗脉络膜新生血管膜的替代疗法。
