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耳蜗传出神经支配中的氨基酸标记模式:一项电子显微镜放射自显影研究。

Amino acid labeling patterns in the efferent innervation of the cochlea: an electron microscopic autoradiographic study.

作者信息

Schwartz I R, Ryan A F

出版信息

J Comp Neurol. 1986 Apr 22;246(4):500-12. doi: 10.1002/cne.902460407.

DOI:10.1002/cne.902460407
PMID:3700725
Abstract

Light microscopic autoradiography and electron microscopic autoradiography were used to study the distribution of label in the cochlear efferents following in vivo incubation with tritiated amino acids. Two basic patterns of labeling were observed. These patterns correspond closely to the lateral and medial superior olivary complex (SOC) olivocochlear systems identified by Warr and Guinan ('79, Brain Res. 173:152-155). Our electron microscopic observations suggest that, at least in the gerbil, the complete separation of outer hair cell (OHC) versus inner hair cell (IHC) efferent innervation proposed by these investigators based upon light microscopic data does not occur. Rather, our data suggest that while the lateral SOC system supplies endings only to the region under the IHC, the medial SOC system may supply endings beneath both the IHCs and OHCs.

摘要

利用光学显微镜放射自显影术和电子显微镜放射自显影术,研究了用氚标记氨基酸进行体内孵育后耳蜗传出纤维中标记物的分布情况。观察到两种基本的标记模式。这些模式与Warr和Guinan(《脑研究》,1979年,第173卷,第152 - 155页)所确定的外侧和内侧上橄榄复合体(SOC)橄榄耳蜗系统密切对应。我们的电子显微镜观察表明,至少在沙鼠中,这些研究者基于光学显微镜数据提出的外毛细胞(OHC)与内毛细胞(IHC)传出神经支配完全分离的情况并未发生。相反,我们的数据表明,虽然外侧SOC系统仅向IHC下方区域提供终末,但内侧SOC系统可能向IHC和OHC下方都提供终末。

相似文献

1
Amino acid labeling patterns in the efferent innervation of the cochlea: an electron microscopic autoradiographic study.耳蜗传出神经支配中的氨基酸标记模式:一项电子显微镜放射自显影研究。
J Comp Neurol. 1986 Apr 22;246(4):500-12. doi: 10.1002/cne.902460407.
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引用本文的文献

1
Structure, pharmacology and function of GABA-A receptors in cochlear outer hair cells.
Eur Arch Otorhinolaryngol. 1993;250(6):351-7. doi: 10.1007/BF00188385.
2
Origin of cochlea efferents in some gerbil species. A comparative anatomical study with fluorescent tracers.
Exp Brain Res. 1988;71(2):252-61. doi: 10.1007/BF00247485.
3
Projection from the inferior colliculus to the superior olivary complex in the albino rat.白化大鼠中从下丘到上橄榄复合体的投射。
Anat Embryol (Berl). 1986;175(1):35-52. doi: 10.1007/BF00315454.
4
A subpopulation of outer hair cells possessing GABA receptors with tonotopic organization.
Arch Otorhinolaryngol. 1989;246(6):417-22. doi: 10.1007/BF00464301.
5
Anatomical mapping of choline acetyltransferase (ChAT)-like and glutamate decarboxylase (GAD)-like immunoreactivity in outer hair cell efferents in adult rats.成年大鼠外毛细胞传出纤维中胆碱乙酰转移酶(ChAT)样和谷氨酸脱羧酶(GAD)样免疫反应性的解剖学定位
Cell Tissue Res. 1991 Oct;266(1):89-95. doi: 10.1007/BF00678715.
6
gamma-Aminobutyric acid receptor activation of outer hair cells in the guinea pig cochlea.豚鼠耳蜗外毛细胞的γ-氨基丁酸受体激活
Eur Arch Otorhinolaryngol. 1992;249(1):62-5. doi: 10.1007/BF00175674.