Natung Tanie, Singh Thangjam Amit, Devi Oinam Somapika, Pandey Ishita
Department of Ophthalmology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.
Oman J Ophthalmol. 2023 Feb 21;16(1):157-160. doi: 10.4103/ojo.ojo_31_22. eCollection 2023 Jan-Apr.
Multiple adverse effects have been reported in people receiving the COVID-19 vaccinations including few reports of optic neuritis. However, there is no report till date, of bilateral optic neuritis post-ChAdOx1-S (recombinant) vaccination. We report here, for the first time, such a case in a previously healthy woman. Although a direct causal relationship cannot be proven, there was a temporal association between the vaccination and the onset of optic neuritis. Some vaccine adjuvants inciting disproportionate systemic inflammation, molecular mimicry, and the hypercoagulable state seen after COVID-19 vaccination could be the possible causes for the development of optic neuritis. Clinicians should be aware of this adverse effect apart from various other adverse effects of COVID-19 vaccination.
在接种新冠疫苗的人群中已报告了多种不良反应，其中包括少数视神经炎的报告。然而，迄今为止，尚无关于接种ChAdOx1-S（重组）疫苗后发生双侧视神经炎的报告。我们在此首次报告一名既往健康女性出现的此类病例。尽管无法证实存在直接因果关系，但疫苗接种与视神经炎发作之间存在时间关联。一些疫苗佐剂引发不成比例的全身炎症、分子模拟以及新冠疫苗接种后出现的高凝状态可能是视神经炎发生的潜在原因。除了新冠疫苗接种的各种其他不良反应外，临床医生也应意识到这种不良反应。
