Nazlı Şerif Bora, Sevindik Muhammet
Department of Psychiatry, Kepez State Hospital, Antalya, Turkey.
Department of Psychiatry, Ordu University School of Medicine, Ordu, Turkey.
Alpha Psychiatry. 2021 Jan 19;22(1):70-72. doi: 10.5455/apd.112405. eCollection 2021 Jan.
Erectile dysfunction and low sexual desire in males are frequently encountered sexual function disorders. Reduced sexual desire or libido is defined as the low frequency of sexual union or achieving orgasm and reduced motivation to initiate or respond to a sexual activity. Individuals with major depression are very frequently observed to have sexual function disorders. It is known that antidepressant agents used for depression treatment are insufficient to regulate sexual function disorder most of the time, whereas some antidepressant agents themselves have side effects of developing a sexual function disorder. Methylphenidate, frequently used for attention-deficit and hyperactivity disorder, is known to affect sexual behavior. Methylphenidate increases dopamine (DA) and norepinephrine (NE) neurotransmission through DA and NE reuptake inhibition. Increases in DA have long been known to increase sexual desire. This article presents the case of a 40-year-old male patient treated with antidepressants who had improvements in erectile dysfunction and loss of libido accompanying depression with the addition of methylphenidate to the treatment.
男性勃起功能障碍和性欲低下是常见的性功能障碍。性欲减退或性欲缺乏被定义为性交频率低或难以达到性高潮，以及发起或回应性活动的动力下降。经常观察到重度抑郁症患者存在性功能障碍。众所周知，用于治疗抑郁症的抗抑郁药大多不足以调节性功能障碍，而一些抗抑郁药本身就有引发性功能障碍的副作用。常用于注意力缺陷多动障碍的哌甲酯已知会影响性行为。哌甲酯通过抑制多巴胺（DA）和去甲肾上腺素（NE）再摄取来增加DA和NE神经传递。长期以来，人们都知道DA增加会增强性欲。本文介绍了一名40岁男性患者的病例，该患者在接受抗抑郁药治疗时，加用哌甲酯后，其伴随抑郁症出现的勃起功能障碍和性欲丧失症状有所改善。
