Qiu Zhongqing, Luo Dongmei, Yin Heng, Chen Yajun, Zhou Zhiwei, Zhang Jing, Zhang Linzhu, Xia Jinrong, Xie Jiang, Sun Qun, Xu Wenming
Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chengdu Third People's Hospital, Chengdu, China.
Front Microbiol. 2023 Mar 16;14:1134517. doi: 10.3389/fmicb.2023.1134517. eCollection 2023.
The gut-brain axis has been widely recognized in autism spectrum disorder (ASD), and probiotics are considered to potentially benefit the rescuing of autism-like behaviors. As a probiotic strain, () was utilized to investigate its effects on gut microbiota and autism-like behaviors in ASD mice constructed by maternal immune activation (MIA).
Adult offspring of MIA mice were given at the dosage of 2 × 10 CFU/g for 4 weeks before subject to the behavior and gut microbiota evaluation.
The behavioral tests showed that intervention was able to rescue autism-like behaviors in mice, including anxiety and depression. In which the treatment group increased the time spent interacting with strangers in the three-chamber test, their activity time and distance in the central area increased in the open field test, and their immobility time decreased when hanging their tails. Moreover, the supplementation of reversed the intestinal flora structure of ASD mice by enhancing the relative abundance of the pivotal microorganisms of and , while reducing those harmful ones like at the genus level.
These results suggested that supplementation may improve autism-like behaviors, possibly regulating the gut microbiota.
肠-脑轴在自闭症谱系障碍（ASD）中已得到广泛认可，益生菌被认为可能有助于挽救自闭症样行为。作为一种益生菌菌株，（）被用于研究其对通过母体免疫激活（MIA）构建的ASD小鼠肠道微生物群和自闭症样行为的影响。
在对MIA小鼠的成年后代进行行为和肠道微生物群评估之前，以2×10 CFU/g的剂量给予（）4周。
行为测试表明，（）干预能够挽救小鼠的自闭症样行为，包括焦虑和抑郁。其中，（）治疗组在三室试验中增加了与陌生人互动的时间，在旷场试验中其在中央区域的活动时间和距离增加，在悬尾试验中其不动时间减少。此外，补充（）通过提高（）和（）关键微生物的相对丰度，同时在属水平上减少（）等有害微生物，逆转了ASD小鼠的肠道菌群结构。
这些结果表明，补充（）可能改善自闭症样行为，可能是通过调节肠道微生物群实现的。
