Kumar Vikrant, Yu Caroline, McGinn Christine K, Perks Krista E, Thompson Sarah M, Sawtell Nathaniel B, Kymissis Ioannis
Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.
Department of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Adv Mater Technol. 2023 Jan 10;8(1). doi: 10.1002/admt.202200354. Epub 2022 Aug 5.
Studies of electrosensory systems have led to insights into to a number of general issues in biology. However, investigations of these systems have been limited by the inability to precisely control spatial patterns of electrosensory input. In this paper, an electrode array and a system to selectively stimulate spatially restricted regions of an electroreceptor array is presented. The array has 96 channels consisting of chrome/gold electrodes patterned on a flexible parylene-C substrate and encapsulated with another parylene-C layer. The conformability of the electrode array allows for optimal current driving and surface interface conditions. Recordings of neural activity at the first central processing stage in weakly electric mormyrid fish support the potential of this system for high spatial resolution stimulation and mapping of electrosensory systems.
对电感应系统的研究已使人们对生物学中的一些一般性问题有了深入了解。然而，对这些系统的研究受到了无法精确控制电感应输入空间模式的限制。本文介绍了一种电极阵列以及一个用于选择性刺激电感受器阵列空间受限区域的系统。该阵列有96个通道，由在柔性聚对二甲苯-C基板上图案化的铬/金电极组成，并被另一个聚对二甲苯-C层封装。电极阵列的顺应性允许实现最佳的电流驱动和表面界面条件。对弱电鳐鱼第一级中央处理阶段神经活动的记录支持了该系统在电感应系统高空间分辨率刺激和绘图方面的潜力。
