默克尔细胞癌：一项挑战。

Merkel cell carcinoma: a challenge.

作者信息

Stawowy L M, Krull E A, Maeda K

出版信息

J Dermatol Surg Oncol. 1986 May;12(5):443-7. doi: 10.1111/j.1524-4725.1986.tb01933.x.

DOI:10.1111/j.1524-4725.1986.tb01933.x

Abstract

A 70-year-old man presented with an enlarging, recurrent tumor of the left buttock which, on initial biopsies, was interpreted as a histiocytic malignant lymphoma. Further biopsies showed numerous monomorphic, hyperchromatic, noncohesive cells, arranged in compact sheets, throughout the dermis, the fat, and the underlying muscle. Neuron specific enolase stain for neuroendocrine granules was positive. Electron microscopy showed cytoplasmic perinuclear microfilaments and round membrane-bound dense core granules. The histologic, enzymatic, and ultrastructural findings confirmed the diagnosis of Merkel cell carcinoma. Early diagnosis and treatment are imperative for a favorable outcome.

摘要

一名70岁男性因左臀部不断增大的复发性肿瘤前来就诊，最初活检结果显示为组织细胞性恶性淋巴瘤。进一步活检发现，在整个真皮、脂肪及下方肌肉中可见大量单形性、核深染、无黏附性的细胞，呈紧密片状排列。神经内分泌颗粒的神经元特异性烯醇化酶染色呈阳性。电子显微镜检查显示有胞质核周微丝和圆形膜结合致密核心颗粒。组织学、酶学及超微结构检查结果均证实为默克尔细胞癌。早期诊断和治疗对于获得良好预后至关重要。