Mata Sabrina, Bussotti Matteo, Del Mastio Monica, Barilaro Alessandro, Piersanti Patrizia, Lombardi Maria, Cincotta Massimo, Torricelli Sara, Leccese Deborah, Sperti Martina, Rodolico Gabriele Rosario, Nacmias Benedetta, Sorbi Sandro
Neurology 1, Dipartimento Neuromuscolo-Scheletrico e Degli Organi di Senso, Univeristy Hospital of Careggi, Florence, Italy.
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
eNeurologicalSci. 2023 Mar 23;31:100457. doi: 10.1016/j.ensci.2023.100457. eCollection 2023 Jun.
The incidence of Amyotrophic Lateral Sclerosis (ALS) varies among different geographical areas and seems to increase over time. This study aimed to examine the epidemiologic data of ALS in the north-east Tuscany and compare the results with those of similar surveys.
Data from ALS cases diagnosed in Florence and Prato Hospitals were prospectively collected from 1st June 2018 to 31st May 2021.
The age- and sex-adjusted incidence rate of ALS in cases per 100,000 population was 2.71 (M/F ratio: 1.21), significantly higher as compared to that reported in the 1967-1976 decade in the same geographical area (0.714). The age- and sex-adjusted incidence rate among resident strangers was similar to that of the general population (2.69). A slightly higher incidence rate (4.36) was observed in the north-east area of Florence province, which includes the Mugello valley. The mean prevalence was of 7.17/100,00. The mean age at diagnosis was 69.7 years, with a peak between 70 and 79 years among men and a smoother age curve among women.
ALS epidemiological features in north-east Tuscany are in line with other Italian and European Centers. The dramatic increase of the local disease burden over the last decades probably reflects better ascertainment methods and health system.
肌萎缩侧索硬化症（ALS）的发病率在不同地理区域有所不同，且似乎随时间增加。本研究旨在调查托斯卡纳东北部ALS的流行病学数据，并将结果与类似调查的结果进行比较。
前瞻性收集2018年6月1日至2021年5月31日在佛罗伦萨和普拉托医院诊断的ALS病例数据。
按年龄和性别调整后的ALS发病率为每10万人口2.71例（男/女比例：1.21），与同一地理区域1967 - 1976十年间报告的发病率（0.714）相比显著更高。常住外地人的年龄和性别调整发病率与普通人群相似（2.69）。在包括穆杰罗山谷的佛罗伦萨省东北部地区观察到略高的发病率（4.36）。平均患病率为7.17/100,00。诊断时的平均年龄为69.7岁，男性在70至79岁之间有一个峰值，女性的年龄曲线较为平缓。
托斯卡纳东北部的ALS流行病学特征与其他意大利和欧洲中心一致。过去几十年当地疾病负担的急剧增加可能反映了更好的确诊方法和卫生系统。
