Abhinav K, Stanton B, Johnston C, Hardstaff J, Orrell R W, Howard R, Clarke J, Sakel M, Ampong M-A, Shaw C E, Leigh P N, Al-Chalabi A
MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK.
Neuroepidemiology. 2007;29(1-2):44-8. doi: 10.1159/000108917. Epub 2007 Sep 24.
BACKGROUND/AIMS: We aimed to estimate the incidence and prevalence of amyotrophic lateral sclerosis (ALS) in the South East of England. The reported incidence of ALS varies between 0.44 and 3.2 per 100,000 person years. This can partly be explained by differences in design and diagnostic criteria used. There is little population data concerning England, particularly the South East.
A population study of South-East England (total population: 2,890,482) was carried out and multiple sources including our tertiary centre and district general hospitals were used for complete case ascertainment.
Between 1 January 2002 and 30 June 2006 we identified 138 people (76 males; 62 females) with a new diagnosis of ALS, giving a crude incidence of 1.06 per 100,000 person years. The projected age- and gender-adjusted annual incidence rate for England and Wales was 1.10 (95% CI 0.80-1.40). 142 people were alive on 30 June 2006, giving a point prevalence of 4.91 per 100,000 population.
Our incidence and prevalence rates are similar to those reported in comparable studies from other countries. This argues against the role of a specific exogenous factor in the aetiology of ALS in South-East England.
背景/目的：我们旨在估算英格兰东南部肌萎缩侧索硬化症（ALS）的发病率和患病率。报道的ALS发病率为每10万人年0.44至3.2例。这部分可以通过所采用的研究设计和诊断标准的差异来解释。关于英格兰，尤其是东南部，几乎没有人口数据。
对英格兰东南部（总人口：2,890,482）进行了一项人口研究，并利用包括我们的三级中心和地区综合医院在内的多个来源来确定全部病例。
在2002年1月1日至2006年6月30日期间，我们确定了138例新诊断为ALS的患者（76例男性；62例女性），粗发病率为每10万人年1.06例。英格兰和威尔士经年龄和性别调整后的预计年发病率为1.10（95%可信区间0.80 - 1.40）。在2006年6月30日有142人存活，点患病率为每10万人口4.91例。
我们的发病率和患病率与其他国家类似研究报道的结果相似。这表明在英格兰东南部ALS的病因中不存在特定外源性因素的作用。
