Viswanathan Vibhu Krishnan, Muthu Sathish
Department of Musculoskeletal Oncology, University of Calgary, Alberta, Canada.
Orthopaedic Research Group, Coimbatore, Tamil Nadu, India.
World Neurosurg X. 2023 Mar 21;18:100185. doi: 10.1016/j.wnsx.2023.100185. eCollection 2023 Apr.
Systematic review of meta-analyses.
To perform a systematic review of meta-analyses to compare the clinical and radiological outcomes following anterior cervical discectomy and fusion with stand-alone cage (SAC) and anterior cervical cage-plate constructs (ACCPC).
The systematic overview was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and reported as per Cochrane Handbook for Systematic Reviews of Interventions following the methodology described in reporting Overview of reviews.
Based on the available level-1 evidence, SAC offers significantly better benefits over ACCPC, in terms of shorter operative time ( < 0.00001; I = 0%), lower blood loss ( = 0.01; I = 0%), lesser rates of post-operative dysphagia ( = 0.02; I = 0%), reduced overall expenditure ( = 0.001) and long-term adjacent segment degeneration (ASD)/anterior longitudinal ligament ossification (ALO; = 0.0003; I = 0%). There is no significant difference between the two constructs with regard to fusion rates, functional outcome scores, follow-up radiological sagittal alignment parameters or cage subsidence.
Based on the available evidence, SAC constructs in ACDF reduce blood loss, decreases operative time, mitigates post-operative dysphagia, lessens hospital-related expenditure and minimises long-term ASD rates.
对荟萃分析的系统评价。
对荟萃分析进行系统评价,以比较单纯椎间融合器(SAC)和颈椎前路椎间融合器钢板结构(ACCPC)在前路颈椎间盘切除融合术后的临床和影像学结果。
本系统综述按照系统评价和荟萃分析的首选报告项目(PRISMA)指南进行,并根据Cochrane干预措施系统评价手册,按照报告综述概述中描述的方法进行报告。
基于现有的一级证据,在手术时间更短(P<0.00001;I²=0%)、失血量更低(P=0.01;I²=0%)、术后吞咽困难发生率更低(P=0.02;I²=0%)、总费用降低(P=0.001)以及长期相邻节段退变(ASD)/前纵韧带骨化(ALO;P=0.0003;I²=0%)方面,SAC比ACCPC具有显著更好的效益。在融合率、功能结局评分、随访影像学矢状位对线参数或椎间融合器下沉方面,两种结构之间没有显著差异。
基于现有证据,ACDF中的SAC结构可减少失血量、缩短手术时间、减轻术后吞咽困难、降低医院相关费用并使长期ASD发生率降至最低。