Schultheis Dorothea, Frasch Manfred
Institute of Neuropathology, Universitätsklinikum Erlangen, University of Erlangen-Nuremberg, Erlangen, Bavaria, Germany.
Division of Developmental Biology, Department of Biology, University of Erlangen-Nuremberg, Erlangen, Bavaria, Germany.
MicroPubl Biol. 2023 Mar 15;2023. doi: 10.17912/micropub.biology.000756. eCollection 2023.
Although the longitudinal visceral muscles have been shown to undergo major morphological changes during the transition from larval to adult gut musculature, there have been conflicting views as to whether these muscles persist as such during metamorphosis or whether they are built anew (Klapper 2000; Aghajanian et al. 2016). Here we present our independent analysis using as a cell type specific marker, which strengthens the proposition by Aghajanian et al. (2016) that the syncytial larval longitudinal gut muscles completely dedifferentiate and fragment into mononucleated myoblasts during pupariation before they fuse again and redifferentiate to form the adult longitudinal gut muscles.
尽管已经表明纵向内脏肌肉在从幼虫肠道肌肉组织向成虫肠道肌肉组织转变的过程中会经历重大的形态变化，但对于这些肌肉在变态过程中是否保持原样，还是会重新构建，存在相互矛盾的观点（克拉珀，2000年；阿加贾尼安等人，2016年）。在这里，我们使用一种细胞类型特异性标记物进行了独立分析，这强化了阿加贾尼安等人（2016年）的观点，即合胞体幼虫纵向肠道肌肉在化蛹期间会完全去分化并分裂成单核成肌细胞，然后再次融合并重新分化形成成虫纵向肠道肌肉。
