在输注放射造影剂期间补体系统的体内研究。

In vivo study of the complement system during infusion of radiographic contrast media.

作者信息

Gardinali M, Cicardi M, Frangi D, Franzinelli M, Gattoni F, Uslenghi C, Agostoni A

出版信息

J Allergy Clin Immunol. 1986 May;77(5):690-2. doi: 10.1016/0091-6749(86)90411-2.

Abstract

It has been claimed that activation of the complement system may play a role in reaction to radiographic contrast media (RCM) infusion. In order to clarify the effects of RCM on the complement system, three different parameters (CH50, C3a, and C1 inhibitor) were measured in 20 patients undergoing intravenous pyelography for diagnostic purposes. We found no significant changes in C3a levels, but CH50 and C1 inhibitor fell significantly at the different sampling times; however, the decreases lost significance when the data were corrected for hemodilution with the total protein content of each sample as a reference. We conclude that RCM infusion does not activate the complement system.

摘要

有人声称补体系统的激活可能在对放射造影剂（RCM）输注的反应中起作用。为了阐明RCM对补体系统的影响，对20名因诊断目的接受静脉肾盂造影的患者测量了三个不同参数（CH50、C3a和C1抑制剂）。我们发现C3a水平没有显著变化，但CH50和C1抑制剂在不同采样时间显著下降；然而，当以每个样本的总蛋白含量为参考对数据进行血液稀释校正后，这些下降就失去了显著性。我们得出结论，RCM输注不会激活补体系统。