Kibret Berhanu Geresu, Canseco-Alba Ana, Onaivi Emmanuel S, Engidawork Ephrem
Department of Biology, College of Science and Health, William Paterson University, Wayne, NJ, United States.
Direction de Investigacion, Instituto Nacional de Neurologia y Neurocircirugia "Manuel Velasco Suarez", Mexico City, Mexico.
Front Behav Neurosci. 2023 Mar 16;17:1137957. doi: 10.3389/fnbeh.2023.1137957. eCollection 2023.
Endocannabinoids (eCBs) and the expanded endocannabinoid system (ECS)-"endocannabinoidome", consists of the endogenous ligands, eCBs, their canonical and non-canonical receptor subtypes, and their synthesizing and metabolizing enzymes. This system modulates a wide range of body functions and acts as a retrograde signaling system within the central nervous system (CNS) by inhibition of classical transmitters, and plays a vital modulatory function on dopamine, a major neurotransmitter in the CNS. Dopamine is involved in different behavioral processes and contributes to different brain disorders-including Parkinson's disease, schizophrenia, and drug addiction. After synthesis in the neuronal cytosol, dopamine is packaged into synaptic vesicles until released by extracellular signals. Calcium dependent neuronal activation results in the vesicular release of dopamine and interacts with different neurotransmitter systems. The ECS, among others, is involved in the regulation of dopamine release and the interaction occurs either through direct or indirect mechanisms. The cross-talk between the ECS and the dopaminergic system has important influence in various dopamine-related neurobiological and pathologic conditions and investigating this interaction might help identify therapeutic targets and options in disorders of the CNS associated with dopamine dysregulation.
内源性大麻素（eCBs）和扩展的内源性大麻素系统（ECS）——“内源性大麻素组”，由内源性配体eCBs、其经典和非经典受体亚型以及它们的合成和代谢酶组成。该系统调节广泛的身体功能，并通过抑制经典递质在中枢神经系统（CNS）内作为逆行信号系统发挥作用，且对中枢神经系统中的主要神经递质多巴胺发挥重要的调节功能。多巴胺参与不同的行为过程，并与不同的脑部疾病有关，包括帕金森病、精神分裂症和药物成瘾。在神经元胞质溶胶中合成后，多巴胺被包装到突触小泡中，直至由细胞外信号释放。钙依赖性神经元激活导致多巴胺从突触小泡释放，并与不同的神经递质系统相互作用。其中，ECS参与多巴胺释放的调节，这种相互作用通过直接或间接机制发生。ECS与多巴胺能系统之间的相互作用在各种与多巴胺相关的神经生物学和病理状况中具有重要影响，研究这种相互作用可能有助于确定与多巴胺调节异常相关的中枢神经系统疾病的治疗靶点和选择。
