高压氧疗法急性治疗视网膜中央动脉阻塞后的长期预后：病例系列
Long-Term Outcomes After Central Retinal Artery Occlusion Treated Acutely With Hyperbaric Oxygen Therapy: A Case Series.
作者信息
John Blegen Halward Martin, Reed Donovan Stephen, Giles Gregory Bryant, Wedel Marissa L, Hobbs Samuel David
机构信息
Department of Ophthalmology, Brooke Army Medical Center, Fort Sam Houston, San Antonio, TX, USA.
Wilford Hall Eye Center, Lackland Air Force Base, San Antonio, TX, USA.
出版信息
J Vitreoretin Dis. 2020 Sep 17;5(2):142-146. doi: 10.1177/2474126420951989. eCollection 2021 Mar-Apr.
PURPOSE
This study assesses the long-term outcomes, including neovascular complications, of central retinal artery occlusion (CRAO) treated acutely with hyperbaric oxygen therapy (HBOT).
METHODS
Four cases of CRAO treated acutely with HBOT were reviewed. Visual and structural outcomes were reviewed. Ocular complications including neovascularization were assessed and risk factors determined.
RESULTS
Two patients with a history of non-insulin dependent diabetes mellitus (NIDDM) developed early-onset ocular neovascularization within 1 month following treatment, with final vision of light perception over 1 year after injury. One patient with NIDDM and 1 patient without NIDDM did not develop ocular neovascularization; both had improvement in final visual acuity to 20/400 and 20/250, respectively.
CONCLUSIONS
Patients treated acutely with HBOT for CRAO may require more frequent and earlier monitoring for complications, especially in patients with diabetes. Further research is needed to determine the long-term safety and efficacy of HBOT for CRAO, especially in the setting of systemic disease such as diabetes.
目的
本研究评估了采用高压氧疗法（HBOT）急性治疗视网膜中央动脉阻塞（CRAO）的长期预后，包括新生血管并发症。
方法
回顾了4例采用HBOT急性治疗的CRAO病例。对视觉和结构预后进行了回顾。评估了包括新生血管形成在内的眼部并发症并确定了危险因素。
结果
2例有非胰岛素依赖型糖尿病（NIDDM）病史的患者在治疗后1个月内出现了早期眼部新生血管形成，受伤1年多后最终视力为光感。1例NIDDM患者和1例无NIDDM患者未出现眼部新生血管形成；二者最终视力分别提高到20/400和20/250。
结论
采用HBOT急性治疗CRAO的患者可能需要更频繁和更早地监测并发症，尤其是糖尿病患者。需要进一步研究以确定HBOT治疗CRAO的长期安全性和有效性，尤其是在糖尿病等全身性疾病的情况下。
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