Lifson Nicole, Salloum George, Kurochkin Philip, Bivona Michael, Yin Han Y, Alpert Samuel
Department of Ophthalmology, State University of New York Upstate Medical Center, Syracuse, New York, U.S.
Undersea Hyperb Med. 2021 Fourth Quarter;48(4):425-430.
Central retinal artery occlusion (CRAO) is a condition that causes sudden vision loss due to obstruction of the retinal artery, typically from a thrombotic or embolic source. It is often associated with atherosclerotic risk factors, including cardiovascular disease, diabetes, hyperlipidemia, and a history of cerebrovascular disease. CRAO often leads to a poor visual outcome as well as neovascularization of the iris, retina, and optic disc, which can exacerbate vision loss and cause pain. While there are several treatment modalities for CRAO, few have been proven to be effective in decreasing the effects of neovascularization. The use of hyperbaric oxygen (HBO2) therapy is often used in the treatment of CRAO due to its ease of use and relatively benign side effect profile. This study aims to assess the degree of improvement in visual acuity (VA) and neovascularization following HBO2. Our data ultimately shows that 20% of patients developed neovascularization after HBO2 compared to 29.8% of those who did not undergo HBO2 (p<.05). Our findings suggest that HBO2 has a statistically significant protective effect against neovascularization and may improve long-term visual acuity.
视网膜中央动脉阻塞（CRAO）是一种由于视网膜动脉阻塞导致突然视力丧失的疾病，通常源于血栓形成或栓子来源。它常与动脉粥样硬化危险因素相关，包括心血管疾病、糖尿病、高脂血症和脑血管疾病史。CRAO常导致视力预后不良以及虹膜、视网膜和视盘新生血管形成，这会加剧视力丧失并引起疼痛。虽然有几种治疗CRAO的方法，但很少有被证明能有效减少新生血管形成的影响。高压氧（HBO2）疗法因其使用方便且副作用相对较小，常用于CRAO的治疗。本研究旨在评估HBO2治疗后视力（VA）和新生血管形成的改善程度。我们的数据最终显示，接受HBO2治疗的患者中有20%出现了新生血管形成，而未接受HBO2治疗的患者中这一比例为29.8%（p<0.05）。我们的研究结果表明，HBO2对新生血管形成具有统计学上显著的保护作用，并可能改善长期视力。
