边缘性 SARS-CoV-2 患者：追踪的痕迹。
Borderline SARS-CoV-2 patients: the trace behind.
机构信息
Department of Microbiology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Department for Clinical Microbiology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
出版信息
Expert Rev Mol Diagn. 2023 Apr;23(4):341-345. doi: 10.1080/14737159.2023.2198641. Epub 2023 Apr 6.
BACKGROUND
Effective and precise SARS-CoV-2 detection assays are crucial for maintaining regular hospital routines and identifying infected hospital employees and infected patients before hospital admission. Inconclusive PCR test results of potentially infectious borderline SARS-CoV-2 patients can confuse clinicians and delay appropriate infection control.
OBJECTIVES AND STUDY DESIGN
In this retrospective study, we followed up borderline SARS-CoV-2 patients who were tested (from the second sample with the same method) at the Clinical Department of Clinical Microbiology. We aimed to determine the positivity conversion ratio within 7 days after inconclusive PCR test results.
RESULTS
Out of 247 borderline patients, who were resampled and retested in the same laboratory, 60 patients (29.4%) showed conversion of the borderline viral load (inconclusive RT-PCR test) to a positive RT-PCR test result.
CONCLUSIONS
Our results highlight the need for retesting of borderline patients with inconclusive SARS-CoV-2 results. Follow-up testing of inconclusive PCR results within 7 days can identify additional positive results and reduce the potential risk of intrahospital transmission.
背景
有效的、准确的 SARS-CoV-2 检测方法对于维持医院的常规运转、识别感染的医院员工和入院前感染的患者至关重要。对于具有潜在传染性的 SARS-CoV-2 边缘病例患者，PCR 检测结果不确定可能会使临床医生感到困惑，并导致适当的感染控制措施延迟。
目的和研究设计
在这项回顾性研究中，我们对临床微生物学临床科接受检测（采用相同方法的第二份样本）的 SARS-CoV-2 边缘病例患者进行了随访。我们旨在确定在 PCR 检测结果不确定后 7 天内阳性转化率。
结果
在重新取样并在同一家实验室进行重复检测的 247 例边缘病例患者中，60 例（29.4%）的边缘病毒载量（不确定的 RT-PCR 检测结果）转变为阳性 RT-PCR 检测结果。
结论
我们的结果强调了需要对 SARS-CoV-2 检测结果不确定的边缘病例患者进行重复检测。在 7 天内对不确定的 PCR 检测结果进行随访检测可以识别更多的阳性结果，降低院内传播的潜在风险。
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