Marmara University, Pendik Research and Training Hospital, Department of Neurology, Istanbul, Turkey.
Bezmialem Vakif University, Faculty of Medicine, Department of Neurology, Istanbul, Turkey.
Ideggyogy Sz. 2023 Mar 30;76(3-4):141-144. doi: 10.18071/isz.76.0141.
Introduction – Methanol is a colorless and highly toxic liquid similar to ethanol in odor and taste. Methanol intake can lead to severe metabolic acidosis, loss of vision, permanent neurological damage, and death.
Case report – We report a case of a 19-year-old female patient who had no known disease history. A large portion of her back was covered in spirits for back pain and kept on for 2 days. Cranial magnetic resonance imaging (MRI) on the 5th day showed hyperintense pathologic signal changes in the T2 sequence without contrast enhancement in the bilateral frontal corticalsubcortical regions and basal ganglia. Following neurological examination of the patient, she was found to have bradymimia, marked resting tremor, bradykinesia, and dystonia on the right upper and lower extremities. Our case is important because it is the only case where parkinsonism developed as a result of acute transdermal methanol intoxication.
引言 – 甲醇是一种无色、高度有毒的液体，其气味和味道与乙醇相似。甲醇摄入可导致严重的代谢性酸中毒、失明、永久性神经损伤和死亡。
病例报告 – 我们报告了一例 19 岁女性患者，她无已知病史。她的大部分背部被酒精覆盖，用于治疗背痛，持续了两天。第 5 天的头颅磁共振成像（MRI）显示双侧额皮质下区域和基底节的 T2 序列出现高信号病理信号改变，无对比增强。对患者进行神经检查后，发现其有运动徐缓、明显的静止性震颤、运动迟缓以及右上下肢的肌张力障碍。我们的病例很重要，因为这是唯一一例因急性经皮甲醇中毒导致帕金森病的病例。
