血清 D-丝氨酸水平对尿毒症患者听力损伤的预测价值。

Predictive value of serum d-serine level for hearing impairment in uremic patients.

机构信息

Department of Nephrology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

Department of Medical Record, The Third People's Hospital of Kunming, Kunming, China.

出版信息

Ren Fail. 2023 Dec;45(1):2194448. doi: 10.1080/0886022X.2023.2194448.

DOI:10.1080/0886022X.2023.2194448

PMID:37009975

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10071898/

Abstract

OBJECTIVE

To investigate the predictive value of serum d-serine level for hearing impairment (HI) in uremic patients.

METHODS

In this study, 30 uremic patients with HI and 30 with normal hearing were selected. The basic conditions, biochemical indicators, and serum serine levels of the two groups were compared to analyze the influencing factors of HI.

RESULTS

The age and d-serine levels were higher in the HI group, while the l-serine level was lower than uremia in the normal hearing group. Logistic regression analysis showed that d-serine level ≥10 μM and older age increased the risk of HI. The area of the receiver operating characteristic (ROC) curve drawn by the prediction probability of HI was 0.838, indicating that age, d-serine, and l-serine had predictive diagnostic values for HI ( < .001). Among these, the ROC curve area of d-serine in predicting HI in uremic patients was 0.822 ( < .001).

CONCLUSIONS

Increased d-serine and age are two risk factors for HI, while l-serine is a protective factor. d-Serine level has a predictive value for HI in uremic patients. Uremic patients are recommended hearing assessment, estimation of d-serine levels, and early intervention.

摘要

目的

探讨血清 d-丝氨酸水平对尿毒症患者听力障碍（HI）的预测价值。

方法

本研究选取 30 例 HI 尿毒症患者和 30 例听力正常的尿毒症患者。比较两组患者的基本情况、生化指标及血清丝氨酸水平，分析 HI 的影响因素。

结果

HI 组年龄和 d-丝氨酸水平较高，而 l-丝氨酸水平较听力正常组低。Logistic 回归分析显示，d-丝氨酸水平≥10μM 和年龄较大增加了 HI 的发病风险。HI 预测概率绘制的受试者工作特征（ROC）曲线下面积为 0.838，表明年龄、d-丝氨酸和 l-丝氨酸对 HI 具有预测诊断价值（ < .001）。其中，d-丝氨酸预测尿毒症患者 HI 的 ROC 曲线下面积为 0.822（ < .001）。