Bon Secours Hospital, College Road, Cork, Ireland.
University College Cork, College Road, Cork, Ireland.
Ir J Med Sci. 2023 Dec;192(6):2707-2712. doi: 10.1007/s11845-023-03346-1. Epub 2023 Apr 3.
Atrial fibrillation is the most common cardiac arrhythmia and is a major risk factor for stroke, with an incidence rate of 4-5% per year. The use of DOACs is recommended for specific patient populations however the risk of bleeding commonly precludes their use. Left atrial appendage occlusion is a relatively novel procedure recommended for such patients. We set out to analyse the initial success and safety of this procedure in a single site.
Twenty patients were included in the study with an average age of 81 years. Seventy percent (n = 14) were male. Ninety percent (n = 18) had a history of major bleeding, an absolute contraindication to anticoagulation. The mean CHADS2VaSc and HASBLED scores were 4.75 and 3.7, respectively. The technical success rate was 95% comparable with existing data. The procedural success rate in our study was 80%. The most frequent complication was cardiac tamponade, occurring in 10% of cases.
We report lower technical success and procedural success rates in an older population cohort than historically studied, 90% of whom had an absolute contraindication to oral anticoagulation, with higher CHADS2VaSc and HASBLED scores than commonly studied.
心房颤动是最常见的心律失常,也是中风的一个主要危险因素,其发病率为每年 4-5%。对于某些特定的患者群体,推荐使用 DOAC 类药物,但出血风险通常会限制其使用。左心耳封堵术是一种针对此类患者的相对较新的治疗方法。我们旨在分析该单一中心的该治疗方法的初始成功率和安全性。
本研究共纳入 20 例患者,平均年龄为 81 岁。70%(n=14)为男性。90%(n=18)有大出血史,这是抗凝治疗的绝对禁忌证。平均 CHADS2VaSc 和 HASBLED 评分分别为 4.75 和 3.7。技术成功率为 95%,与现有数据相当。本研究中的手术成功率为 80%。最常见的并发症是心脏压塞,发生率为 10%。
我们报告了在一个年龄较大的患者群体中,技术成功率和手术成功率低于历史研究,其中 90%的患者有口服抗凝治疗的绝对禁忌证,且 CHADS2VaSc 和 HASBLED 评分高于通常研究的评分。