AL-BAYAN UNIVERSITY, BAGHDAD, IRAQ.
AL-MUSTANSIRIYAH UNIVERSITY, BAGHDAD, IRAQ.
Wiad Lek. 2023;76(2):360-369. doi: 10.36740/WLek202302117.
The aim: The current study was designed for evaluation the effect of oral magnesium l-lactate supplementation on blood pressure and corrected QT interval in a sample of Iraqi women.
Materials and methods: In this interventional prospective randomized trial, 58 female patients diagnosed with MetS according to the International Diabetic Federation (IDF) criteria and were randomly allocated to receive either placebo or magnesium l-lactate 84 mg, twice daily.
Results: O#ce blood pressure showed a signi$cant drop in systolic blood pressure (SBP) (P<0.05), non-significant decline in diastolic blood pressure (DBP), heart rate (HR), and pulse pressure (PP) (P>0.05), while ambulatory blood pressure monitoring (ABPM) recorded a signi$cant reduction in HR in patients on magnesium supplement. Also, there was a signi$cant decline in the SBP (P<0.05) and non-signi$cant decline in DBP and PP (P>0.05) in patients with masked hypertension on Mg supplement. The changes in corrected QT- interval had no signi$cant e"ect within Mg group (P>0.05).
Conclusions: From above results, one can conclude that oral Mg l-lactate supplement can improve, to a certain extent, blood pressure of women with MetS. Further studies in this aspect may be required.
本研究旨在评估口服 L-乳酸镁补充对伊拉克女性血压和校正 QT 间期的影响。
在这项干预性前瞻性随机试验中，根据国际糖尿病联合会 (IDF) 标准诊断为代谢综合征 (MetS) 的 58 名女性患者被随机分配接受安慰剂或 L-乳酸镁 84mg，每日两次。
诊室血压显示收缩压 (SBP) 显著下降（P<0.05），舒张压 (DBP)、心率 (HR) 和脉压 (PP) 无显著下降（P>0.05），而动态血压监测 (ABPM) 记录镁补充患者 HR 显著降低。此外，在服用镁补充剂的隐匿性高血压患者中，SBP（P<0.05）显著下降，DBP 和 PP 非显著下降（P>0.05）。镁组校正 QT 间期的变化无显著影响（P>0.05）。
从上述结果可以得出结论，口服 L-乳酸镁补充剂可以在一定程度上改善代谢综合征女性的血压。在这方面可能需要进一步的研究。
