Department of Otolaryngology, Head & Neck Surgery and Audiology, 6033, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging & Department of Biomedical Sciences, Copenhagen University Hospital, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Eur Arch Otorhinolaryngol. 2023 Jul;280(7):3393-3403. doi: 10.1007/s00405-023-07939-5. Epub 2023 Apr 3.
The purpose was to investigate the diagnostic performance of bimodal optical and radio-guided sentinel node biopsy (SNB) for oral squamous cell carcinoma (OSCC) sub-sites in the anterior oral cavity.
Prospective study of 50 consecutive patients with cN0 OSCC scheduled for SNB was injected with the tracer complex Tc99m:ICG:Nacocoll. A near-infrared camera was applied for optical SN detection. Endpoints were modality for intraoperative SN detection and false omission rate at follow-up.
In all patients, a SN could be detected. In 12/50 (24%) of cases, the SPECT/CT showed no focus in level 1, but intraoperatively a SN in level 1 was optically detected. In 22/50 cases (44%), an additional SN was identified only due to the optical imaging. At follow-up, the false omission rate was 0%.
Optical imaging appears to be an effective tool to allow real-time SN identification comprising level 1 unaffected by possible interference of radiation site from the injection.
旨在研究双模式光学和放射性示踪前哨淋巴结活检（SNB）在口腔前腔 OSCC 亚部位的诊断性能。
对 50 例拟行 SNB 的 cN0 口腔鳞状细胞癌（OSCC）连续患者进行前瞻性研究，注入示踪复合物 Tc99m：ICG：Nacocoll。应用近红外摄像机进行光学 SN 检测。终点是术中 SN 检测的方式和随访时的假遗漏率。
在所有患者中，均可检测到 SN。在 50 例中的 12 例（24%），SPECT/CT 显示 1 级无焦点，但术中光学检测到 1 级的 SN。在 22/50 例（44%）中，仅由于光学成像才能识别出额外的 SN。随访时，假遗漏率为 0%。
光学成像似乎是一种有效的工具，可实时识别 SN，包括不受注射部位辐射干扰的 1 级。
