光学和放射性核素引导下的前哨淋巴结活检术在口腔前腔鳞状细胞癌颈部分期中的诊断准确性。
Diagnostic accuracy of combined optical- and radio-guided SNB for neck staging of oral squamous cell carcinoma lesions in the anterior oral cavity.
机构信息
Department of Otolaryngology, Head & Neck Surgery and Audiology, 6033, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging & Department of Biomedical Sciences, Copenhagen University Hospital, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
出版信息
Eur Arch Otorhinolaryngol. 2023 Jul;280(7):3393-3403. doi: 10.1007/s00405-023-07939-5. Epub 2023 Apr 3.
PURPOSE
The purpose was to investigate the diagnostic performance of bimodal optical and radio-guided sentinel node biopsy (SNB) for oral squamous cell carcinoma (OSCC) sub-sites in the anterior oral cavity.
METHODS
Prospective study of 50 consecutive patients with cN0 OSCC scheduled for SNB was injected with the tracer complex Tc99m:ICG:Nacocoll. A near-infrared camera was applied for optical SN detection. Endpoints were modality for intraoperative SN detection and false omission rate at follow-up.
RESULTS
In all patients, a SN could be detected. In 12/50 (24%) of cases, the SPECT/CT showed no focus in level 1, but intraoperatively a SN in level 1 was optically detected. In 22/50 cases (44%), an additional SN was identified only due to the optical imaging. At follow-up, the false omission rate was 0%.
CONCLUSION
Optical imaging appears to be an effective tool to allow real-time SN identification comprising level 1 unaffected by possible interference of radiation site from the injection.
目的
旨在研究双模式光学和放射性示踪前哨淋巴结活检（SNB）在口腔前腔 OSCC 亚部位的诊断性能。
方法
对 50 例拟行 SNB 的 cN0 口腔鳞状细胞癌（OSCC）连续患者进行前瞻性研究，注入示踪复合物 Tc99m：ICG：Nacocoll。应用近红外摄像机进行光学 SN 检测。终点是术中 SN 检测的方式和随访时的假遗漏率。
结果
在所有患者中，均可检测到 SN。在 50 例中的 12 例（24%），SPECT/CT 显示 1 级无焦点，但术中光学检测到 1 级的 SN。在 22/50 例（44%）中，仅由于光学成像才能识别出额外的 SN。随访时，假遗漏率为 0%。
结论
光学成像似乎是一种有效的工具，可实时识别 SN，包括不受注射部位辐射干扰的 1 级。
Zotero 插件