van Ek B, Bakker F P, van Dulken H, Dijkmans B A
J Infect. 1986 Mar;12(2):105-9. doi: 10.1016/s0163-4453(86)93483-3.
A retrospective study was performed to evaluate the rate of infection directly related to craniotomy. Of 246 craniotomies performed in 1981, 234 could be evaluated. The overall incidence of infection was 8.1% (19 infections in 18 patients). The infection rate was 15.2% after insertion of a ventricular shunt (seven infections after 45 ventriculostomies). Staphylococcus aureus, Staphylococcus epidermidis and Propionibacterium acnes were the most frequent isolated micro-organisms. We recommended a double-blind prospective study to evaluate the possible benefit of antibiotic prophylaxis in craniotomies.
进行了一项回顾性研究，以评估与开颅手术直接相关的感染率。1981年进行的246例开颅手术中，234例可进行评估。感染的总体发生率为8.1%（18例患者中有19例感染）。插入脑室分流管后的感染率为15.2%（45次脑室造口术后有7例感染）。金黄色葡萄球菌、表皮葡萄球菌和痤疮丙酸杆菌是最常分离出的微生物。我们建议进行一项双盲前瞻性研究，以评估抗生素预防在开颅手术中可能带来的益处。
