Center for Reproductive Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China.
Center for Reproductive Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China.
Diagn Microbiol Infect Dis. 2023 Jun;106(2):115940. doi: 10.1016/j.diagmicrobio.2023.115940. Epub 2023 Mar 12.
The correlations of joint detection of 22 vaginal microbes with routine examination results of vaginal secretions and assisted reproductive outcomes were investigated. There were 37 samples with abnormal vaginal microecology in 107 vaginal secretion samples. The top 5 detection rates of microorganisms were Ureaplasma urealyticum (73.83%), Prevotella sp. (70.09%), Gardnerella vaginalis (53.27%), L. crispatus (52.34%) and L. inerts (51.40%). When the levels of Bacillus and hydrogen peroxide in vaginal secretions decreased or pH increased, the abnormal rates of vaginal microecology increased significantly (P < 0.01). The clinical pregnancy rate (53.66%, 22/41) in the women with normal vaginal microecology was higher than that (37.5%, 9/24) with abnormal vaginal microecology. In conclusions, the joint detection of 22 vaginal microbes can quickly and effectively determine whether the vaginal microecology is normal or not. The evaluation of vaginal microecology may be valuable in predicting the assisted reproductive outcomes of infertile women.
本研究旨在探讨 22 种阴道微生物的联合检测与阴道分泌物常规检查结果及辅助生殖结局的相关性。在 107 例阴道分泌物样本中，有 37 例阴道微生态异常。微生物检测的前 5 位检出率分别为解脲脲原体（73.83%）、普雷沃菌属（70.09%）、阴道加德纳菌（53.27%）、卷曲乳杆菌（52.34%）和惰性乳杆菌（51.40%）。当阴道分泌物中杆菌和过氧化氢水平降低或 pH 值升高时，阴道微生态异常率显著升高（P<0.01）。阴道微生态正常的患者临床妊娠率（53.66%，22/41）高于阴道微生态异常的患者（37.5%，9/24）。综上所述，22 种阴道微生物的联合检测可快速、有效地判断阴道微生态是否正常。阴道微生态的评估可能有助于预测不孕患者的辅助生殖结局。
