Sahgal V, Hast M H
J Laryngol Otol. 1986 May;100(5):553-60. doi: 10.1017/s0022215100099667.
Primate intrinsic laryngeal muscles studied consisted of Type I and Type II fibres. Type II fibres were larger than Type I fibres. The coefficient of variance of these muscles suggested that the fibre-size variation was similar in all of these muscles. Denervation resulted in shrinking of Type II fibres at two weeks in all the muscles, while at four weeks the thyroarytenoid showed an inflammatory reaction and far greater reduction in size than the other muscles. At eight weeks, however, all the muscles were fibrosed. We conclude that laryngeal muscles begin to show evidence of denervation at two weeks and are fibrosed in eight weeks. The thyroarytenoid muscle showed inflammatory degeneration, while the posterior cricoarytenoid and cricothyroid muscles showed classical changes of denervation. These findings should have clinical significance in the timing of reinnervation procedures.
所研究的灵长类动物喉内肌由I型和II型纤维组成。II型纤维比I型纤维大。这些肌肉的变异系数表明，所有这些肌肉的纤维大小变化相似。去神经支配导致所有肌肉中的II型纤维在两周时萎缩，而在四周时，甲杓肌出现炎症反应，且其大小减小幅度远大于其他肌肉。然而，在八周时，所有肌肉均发生纤维化。我们得出结论，喉内肌在两周时开始出现去神经支配的迹象，并在八周时发生纤维化。甲杓肌表现出炎症性退变，而环杓后肌和环甲肌表现出典型的去神经支配变化。这些发现对于神经再支配手术的时机选择应具有临床意义。
