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Noninferiority of the hydroxy analog of methionine compared to DL-methionine not confirmed in a broiler trial.

作者信息

Lemme Andreas, Piepho Hans-Peter

机构信息

Evonik Operations GmbH, 63457 Hanau, Germany.

Bioinformatics Unit, University of Hohenheim, 70593 Stuttgart, Germany.

出版信息

Poult Sci. 2023 Jul;102(7):102644. doi: 10.1016/j.psj.2023.102644. Epub 2023 Mar 11.

DOI:10.1016/j.psj.2023.102644
PMID:37012140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10311155/
Abstract
摘要

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1
Noninferiority of the hydroxy analog of methionine compared to DL-methionine not confirmed in a broiler trial.在一项肉鸡试验中，未证实蛋氨酸羟基类似物相对于DL-蛋氨酸具有非劣效性。
Poult Sci. 2023 Jul;102(7):102644. doi: 10.1016/j.psj.2023.102644. Epub 2023 Mar 11.
2
New statistical approach shows that hydroxy-methionine is noninferior to DL-Methionine in 35-day-old broiler chickens.新的统计方法表明，在 35 日龄肉鸡中，羟基蛋氨酸不亚于 DL-蛋氨酸。
Poult Sci. 2023 Apr;102(4):102519. doi: 10.1016/j.psj.2023.102519. Epub 2023 Jan 21.
3
Response to letter to the editor titled: Noninferiority of the hydroxy analog of methionine compared to DL-methionine not confirmed in a broiler trial.对编辑来信的回复，信的标题为：在一项肉鸡试验中未证实蛋氨酸羟基类似物与DL-蛋氨酸相比具有非劣效性。
Poult Sci. 2023 Jul;102(7):102643. doi: 10.1016/j.psj.2023.102643. Epub 2023 Mar 17.
4
Intestinal permeability, microbiota composition, and expression of genes related to intestinal barrier function of broiler chickens fed different methionine sources supplemented at varying concentrations.饲粮中不同蛋氨酸源及其添加水平对肉鸡肠道通透性、微生物组成和肠道屏障功能相关基因表达的影响
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Evaluating growth response of broiler chickens fed diets supplemented with synthetic DL-methionine or DL-hydroxy methionine: a meta-analysis.评估饲粮添加合成 DL-蛋氨酸或 DL-羟基蛋氨酸对肉鸡生长性能的影响：一项荟萃分析。
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Changes in cecum microbial community in response to total sulfur amino acid (TSAA: DL-methionine) in antibiotic-free and supplemented poultry birds.无抗及添加硫氨基酸（DL-蛋氨酸）条件下家禽盲肠微生物群落变化。
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引用本文的文献

1
Meta-Analyses of Methionine Source Concept Validation Trials in Broilers.肉鸡蛋氨酸来源概念验证试验的Meta分析
Animals (Basel). 2024 Jun 12;14(12):1771. doi: 10.3390/ani14121771.
2
Response to letter to the editor titled: Noninferiority of the hydroxy analog of methionine compared to DL-methionine not confirmed in a broiler trial.对编辑来信的回复，信的标题为：在一项肉鸡试验中未证实蛋氨酸羟基类似物与DL-蛋氨酸相比具有非劣效性。
Poult Sci. 2023 Jul;102(7):102643. doi: 10.1016/j.psj.2023.102643. Epub 2023 Mar 17.

本文引用的文献

1
New statistical approach shows that hydroxy-methionine is noninferior to DL-Methionine in 35-day-old broiler chickens.新的统计方法表明，在 35 日龄肉鸡中，羟基蛋氨酸不亚于 DL-蛋氨酸。
Poult Sci. 2023 Apr;102(4):102519. doi: 10.1016/j.psj.2023.102519. Epub 2023 Jan 21.
2
Utilization of Methionine Sources for Growth and Met+Cys Deposition in Broilers.蛋氨酸来源在肉鸡生长及蛋氨酸+半胱氨酸沉积中的利用
Animals (Basel). 2020 Nov 29;10(12):2240. doi: 10.3390/ani10122240.
3
Through the looking glass: understanding non-inferiority.透过玻璃看：理解非劣效性。
Trials. 2011 May 3;12:106. doi: 10.1186/1745-6215-12-106.
4
No evidence for different dose responses of commercial methionine sources in broilers.没有证据表明肉鸡对商业蛋氨酸来源存在不同的剂量反应。
Poult Sci. 2006 Dec;85(12):2047. doi: 10.1093/ps/85.12.2047.
5
Evidence for 2-hydroxy-4(methylthio) butanoic acid and DL-methionine having different dose responses in growing broilers.2-羟基-4-（甲硫基）丁酸和DL-蛋氨酸在生长肉鸡中具有不同剂量反应的证据。
Poult Sci. 2006 Aug;85(8):1409-20. doi: 10.1093/ps/85.8.1409.
6
On non-inferiority analysis based on delta-method confidence intervals.基于德尔塔法置信区间的非劣效性分析。
J Biopharm Stat. 2003 Aug;13(3):565-83. doi: 10.1081/BIP-120022775.
7
Design and analysis of non-inferiority mortality trials in oncology.肿瘤学中非劣效性死亡率试验的设计与分析
Stat Med. 2003 Jan 30;22(2):239-64. doi: 10.1002/sim.1400.