Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental University Hospital, University of Dublin, Trinity College Dublin, Dublin, Ireland.
Essays Biochem. 2023 Sep 13;67(5):843-851. doi: 10.1042/EBC20220238.
Mediator is a complex of polypeptides that plays a central role in the recruitment of RNA polymerase II to promoters and subsequent transcriptional activation in eukaryotic organisms. Studies have now shown that Mediator has a role in regulating expression of genes implicated in virulence and antifungal drug resistance in pathogenic fungi. The roles of specific Mediator subunits have been investigated in several species of pathogenic fungi, particularly in the most pathogenic yeast Candida albicans. Uniquely, pathogenic yeast also present several interesting examples of divergence in Mediator structure and function, most notably in C. glabrata, which possesses two orthologues of Med15, and in C. albicans, which has a massively expanded family of Med2 orthologues known as the TLO gene family. This review highlights specific examples of recent progress in characterizing the role of Mediator in pathogenic fungi.
中介体是一种多肽复合物，在真核生物中，它在 RNA 聚合酶 II 招募到启动子并随后进行转录激活中起着核心作用。研究表明，中介体在调节与致病性真菌毒力和抗真菌药物耐药性相关的基因表达方面发挥作用。在几种致病性真菌中，特别是在最具致病性的酵母白色念珠菌中，已经研究了特定中介体亚基的作用。独特的是，致病性酵母在中介体结构和功能上也存在一些有趣的分化例子，最值得注意的是在光滑念珠菌中，它拥有两个 Med15 的同源物，而在白色念珠菌中，它拥有一个大量扩展的 Med2 同源物家族，称为 TLO 基因家族。这篇综述强调了最近在表征中介体在致病性真菌中的作用方面取得的具体进展。
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