Sapozink M D, Gibbs F A, Egger M J, Stewart J R
J Clin Oncol. 1986 May;4(5):775-83. doi: 10.1200/JCO.1986.4.5.775.
Twenty-eight patients with advanced upper-abdominal malignancy were treated at the University of Utah on a pilot protocol involving regional hyperthermia (HT) produced by the BSD-1000 HT system and the annular phased array applicator (AA), usually driven at 60 MHz. Eighty-two percent of the patients had widespread metastatic disease, and the mean tumor burden was 2,900 cc. Seventy-nine percent of the patients received concurrent radiotherapy. Acute toxicity consisted primarily of pain within the AA aperture (43%), systemic stress (43%), and nausea or vomiting (29%). Systemic stress was the most frequent power-limiting factor (46%). There were two treatment-related complications: sciatic neuritis from intramuscular injection (one) and pleural effusion from thermometry probe placement (one). Detailed thermal mapping and thermal dosimetry were performed on 26 patients. The mean thermal dosimetry parameters were quite low. Concurrent radiation doses were also quite low (mean, 1,500 rad) to avoid toxicity of sensitive organ systems within the abdomen. The objective response rate was only 18%, all partial, but 43% of the patients achieved effective symptomatic palliation. The five objective responders did survive significantly (P = .02) longer than the 23 nonresponders.
犹他大学依据一项试验方案，对28例晚期上腹部恶性肿瘤患者进行了治疗，该方案涉及使用BSD - 1000热疗系统和环形相控阵辐射器（AA）产生区域热疗（HT），通常以60兆赫兹驱动。82%的患者有广泛转移性疾病，平均肿瘤负荷为2900立方厘米。79%的患者接受了同步放疗。急性毒性主要包括AA辐射器孔径内疼痛（43%）、全身应激（43%）以及恶心或呕吐（29%）。全身应激是最常见的功率限制因素（46%）。有两例与治疗相关的并发症：一例因肌肉注射导致坐骨神经炎，一例因放置测温探头导致胸腔积液。对26例患者进行了详细的热成像和热剂量测定。平均热剂量测定参数相当低。同步放疗剂量也相当低（平均1500拉德），以避免腹部敏感器官系统出现毒性。客观缓解率仅为18%，均为部分缓解，但43%的患者实现了有效的症状缓解。5例客观缓解者的生存期明显（P = 0.02）长于23例未缓解者。
