Department of Emergency Medicine and Department of Biomedical and Clinical Sciences, Linköping University, 581 85, Linköping, Sweden.
Sci Rep. 2023 Apr 4;13(1):5469. doi: 10.1038/s41598-023-32637-x.
To establish the impact of COVID-19 on the pre-test probability for VTE in patients with suspected VTE. This was a retrospective, observational, cross-sectional study of patients 18 years and older undergoing diagnostic tests for VTE in an integrated healthcare system covering a population of 465,000 during the calendar year of 2020. We adjusted for risk factors such as age, sex, previous VTE, ongoing anticoagulant treatment, malignancy, Charlson score, ward care, ICU care and wave of COVID-19. In total, 303 of 5041 patients had a positive diagnosis of COVID-19 around the time of investigation. The prevalence of VTE in COVID-positive patients was 10.2% (36/354), 14.7% (473/3219) in COVID-19 negative patients, and 15.6% (399/2589) in patients without a COVID-19 test. A COVID-positive status was not associated with an increased risk for VTE (crude odds ratio 0.64, 95% CI 0.45-0.91, adjusted odds ratio 0.46, 95%CI 0.19-1.16). We found no increased VTE risk in COVID-positive patients. This indicates that COVID-19 status should not influence VTE workup.The study was pre-registered on May 26, 2020 at ClinicalTrials.gov with identifier NCT04400877.
确定 COVID-19 对疑似静脉血栓栓塞症（VTE）患者 VTE 前预测概率的影响。这是一项回顾性、观察性、横断面研究，纳入了在 2020 年接受 VTE 诊断性检查的 18 岁及以上的患者，该研究在一个覆盖 46.5 万人群的综合性医疗保健系统中进行。我们调整了年龄、性别、既往 VTE、持续抗凝治疗、恶性肿瘤、Charlson 评分、病房护理、重症监护病房护理和 COVID-19 波次等风险因素。共有 5041 例患者中有 303 例在调查时患有 COVID-19。COVID-19 阳性患者的 VTE 患病率为 10.2%（36/354），COVID-19 阴性患者为 14.7%（473/3219），无 COVID-19 检测的患者为 15.6%（399/2589）。COVID-19 阳性状态与 VTE 风险增加无关（粗比值比 0.64，95%CI 0.45-0.91，调整比值比 0.46，95%CI 0.19-1.16）。我们未发现 COVID-19 阳性患者的 VTE 风险增加。这表明 COVID-19 状态不应影响 VTE 检查。该研究于 2020 年 5 月 26 日在 ClinicalTrials.gov 上进行了预先注册，登记号为 NCT04400877。
