Department of Neurosurgery, University of Maryland School of Medicine, 10 South Pine Street, MSTF 823, Baltimore, MD, 21201, USA.
Department of Orthopedics, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Transl Stroke Res. 2024 Jun;15(3):495-497. doi: 10.1007/s12975-023-01150-8. Epub 2023 Apr 4.
Global ischemic brain injury is the leading cause of mortality and long-term disability in patients resuscitated from cardiac arrest. Hypothermia and neuroprotective agents are two strategies partially improve neurological outcomes following resuscitation. However, the therapeutic effects of these treatments are inconsistently reported. Stem cell therapy has emerged as a promising protective strategy due to its potential for proliferation and differentiation into functional neural cells. This editorial reviews the current status of stem cell therapy via the intranasal route in primates and clinical studies, along with the treatment window of stem cell therapy in ischemic brain injury after cardiac arrest to provide new insight into stem cell therapy for cardiac arrest-induced global cerebral ischemia injury.
全球缺血性脑损伤是心肺复苏后患者死亡和长期残疾的主要原因。低温和神经保护剂是两种策略，部分改善了复苏后的神经预后。然而，这些治疗方法的治疗效果并不一致。由于其增殖和分化为功能性神经细胞的潜力，干细胞治疗已成为一种有前途的保护策略。本社论通过鼻内途径在灵长类动物和临床研究中综述了干细胞治疗的现状，以及心肺复苏后缺血性脑损伤的干细胞治疗时间窗，为心肺复苏引起的全脑缺血损伤的干细胞治疗提供新的见解。
