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感染与炎症后颈椎畸形的发生率、变化及治疗

The Incidence, Changes and Treatments of Cervical Deformity After Infection and Inflammation.

作者信息

Han Bo, Wang Jianqiang, Hai Yong, Sun Duan, Liang Weishi, Yin Peng, Ding Hongtao

机构信息

Department of Orthopedics, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

出版信息

Neurospine. 2023 Mar;20(1):205-220. doi: 10.14245/ns.2244744.372. Epub 2023 Mar 31.

DOI:10.14245/ns.2244744.372
PMID:37016867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10080454/
Abstract

A healthy cervical spine with normal movement is the basis of many daily activities and is essential for maintaining a good quality of life. However, the alignment, fusion, and structure of the cervical spine can change for various reasons, leading to cervical deformity, mainly kyphosis. Approximately 5%‒20% of spinal infections in the cervical spine cause cervical deformity. The deformity can recover early; however, the disease's long-term existence or the continuous action of abnormal stress may lead to intervertebral fusion and abnormal osteophytes. Many gaps and controversies exist regarding infectious cervical deformities, including a lack of clear definitions and an acceptable classification system thereby requiring further research. Moreover, there is no consensus on the indications for postinfectious cervical deformity associated with Mycobacterium tuberculosis, Staphylococcus aureus, and Brucellosis. Therefore, we reviewed and discussed the incidence, clinical manifestations, changes, and treatment of infectious and inflammatory secondary cervical deformities from common to rare to provide a theoretical basis for clinical decision-making.

摘要

健康且活动正常的颈椎是许多日常活动的基础,对于维持良好生活质量至关重要。然而,颈椎的排列、融合及结构可能因各种原因发生改变,导致颈椎畸形,主要是后凸畸形。颈椎脊柱感染中约5%‒20%会导致颈椎畸形。畸形可能早期恢复;然而,疾病的长期存在或异常应力的持续作用可能导致椎间融合和异常骨赘形成。关于感染性颈椎畸形存在许多差距和争议,包括缺乏明确的定义和可接受的分类系统,因此需要进一步研究。此外,对于与结核分枝杆菌、金黄色葡萄球菌和布鲁氏菌病相关的感染后颈椎畸形的适应症尚无共识。因此,我们回顾并讨论了从常见到罕见的感染性和炎症性继发性颈椎畸形的发病率、临床表现、变化及治疗方法,为临床决策提供理论依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b3/10080454/68f4957af186/ns-2244744-372f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b3/10080454/aafdd99f65d0/ns-2244744-372f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b3/10080454/68f4957af186/ns-2244744-372f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b3/10080454/aafdd99f65d0/ns-2244744-372f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b3/10080454/68f4957af186/ns-2244744-372f2.jpg

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本文引用的文献

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Surg Neurol Int. 2022 May 13;13:198. doi: 10.25259/SNI_167_2022. eCollection 2022.
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Efficacy of anterior debridement and bone grafting with fusion using internal fixation combined with anti-tuberculosis chemotherapy in the treatment of subaxial cervical tuberculosis.前路清创植骨融合内固定联合抗结核化疗治疗下颈椎结核的疗效。
BMC Surg. 2022 Apr 27;22(1):150. doi: 10.1186/s12893-022-01606-y.
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Chronological Analysis of Primary Cervical Spine Infection: A Single-Center Analysis of 59 Patients over Three Decades (1992-2018).
脊柱结核与布鲁氏菌性脊柱炎术前非侵入性鉴别诊断的差异分析
Eur Spine J. 2025 Feb;34(2):675-683. doi: 10.1007/s00586-025-08647-w. Epub 2025 Jan 7.
原发性颈椎感染的时间顺序分析:三十年(1992 - 2018年)间59例患者的单中心分析
J Clin Med. 2022 Apr 15;11(8):2210. doi: 10.3390/jcm11082210.
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Surgical treatment of the lower cervical brucellosis with osteoporosis in the northwest region of China: review of 22 cases.中国西北地区下颈椎布氏杆菌病合并骨质疏松症的外科治疗:22例病例回顾
Am J Transl Res. 2022 Feb 15;14(2):909-917. eCollection 2022.
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Nat Rev Microbiol. 2022 Jul;20(7):385-400. doi: 10.1038/s41579-022-00686-0. Epub 2022 Feb 15.
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