Department of Ophthalmology, Nara Medical University School of Medicine, Nara.
Yoshikawa Eye Clinic, Osaka.
J Hypertens. 2023 Jun 1;41(6):1018-1023. doi: 10.1097/HJH.0000000000003429. Epub 2023 Apr 4.
Glaucoma is reportedly associated with asymmetric dimethylarginine (ADMA) and circadian blood pressure (BP) variability, including night-time SBP. We determined whether ADMA level is associated with night-time SBP in patients with glaucoma.
In this cross-sectional study, we measured the serum ADMA level and ambulatory BP of 163 patients with glaucoma and 705 participants without glaucoma. Based on the tertiles of serum ADMA level, the patients were divided into three groups: low, intermediate, and high-ADMA. Night-time SBP was determined based on ambulatory BP measured every 30 min for 48 h. The nondipper BP pattern was defined as having a night-time mean SBP decline of less than 10% relative to the mean daytime SBP.
In the glaucoma group, the night-time SBP in the high-ADMA group was significantly higher than in the low-ADMA group (123.0 and 114.4 mmHg, respectively; P = 0.003). Multivariable analysis adjusted for the potential confounders showed the night-time SBP, and the odds ratio for nondipper in the high-ADMA group were also significantly higher than in the low-ADMA group ( P = 0.030 and P = 0.021, respectively). Significant associations between continuous serum ADMA levels with night-time SBP and nondipper were also found ( P = 0.002 and 0.006, respectively). In the control group, however, no significant associations were found between serum ADMA levels and night-time SBP and nondipper. A significant interaction effect of the serum ADMA levels and glaucoma on nondipper was found ( P = 0.004).
Serum ADMA level was significantly associated with the disturbance of circadian BP variability in patients with glaucoma.
据报道，青光眼与不对称二甲基精氨酸（ADMA）和昼夜血压（BP）变异性有关，包括夜间收缩压（SBP）。我们确定 ADMA 水平是否与青光眼患者的夜间 SBP 相关。
在这项横断面研究中，我们测量了 163 例青光眼患者和 705 例无青光眼患者的血清 ADMA 水平和动态血压。根据血清 ADMA 水平的三分位数，患者被分为三组：低、中、高 ADMA。夜间 SBP 基于 48 小时内每 30 分钟测量一次的动态血压确定。非杓型血压模式定义为夜间平均 SBP 相对于白天平均 SBP 的下降幅度小于 10%。
在青光眼组中，高 ADMA 组的夜间 SBP 明显高于低 ADMA 组（分别为 123.0 和 114.4mmHg；P = 0.003）。多变量分析调整了潜在混杂因素后，高 ADMA 组的夜间 SBP 和非杓型的比值比也明显高于低 ADMA 组（P = 0.030 和 P = 0.021，分别）。连续血清 ADMA 水平与夜间 SBP 和非杓型之间也存在显著关联（P = 0.002 和 0.006，分别）。然而，在对照组中，血清 ADMA 水平与夜间 SBP 和非杓型之间没有显著关联。血清 ADMA 水平与青光眼对非杓型的交互作用有显著影响（P = 0.004）。
血清 ADMA 水平与青光眼患者昼夜血压变异性紊乱显著相关。
