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纹状体 NG2 胶质细胞在帕金森病大鼠左旋多巴诱导运动障碍中的动态作用：强力霉素的影响。

Dynamic Involvement of Striatal NG2-glia in L-DOPA Induced Dyskinesia in Parkinsonian Rats: Effects of Doxycycline.

机构信息

Department of Oral and Basic Biology, Faculty of Odontology of Ribeirao Preto, 28133University of Sao Paulo, Sao Paulo, Brazil.

Department of Molecular, Cellular, and Developmental Neurobiology, Instituto Cajal -CSIC-, Spanish National Research Council, Madrid, Spain.

出版信息

ASN Neuro. 2023 Jan-Dec;15:17590914231155976. doi: 10.1177/17590914231155976.

DOI:10.1177/17590914231155976
PMID:37017068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10084551/
Abstract

NG2-glia alters its dynamics in response to L-DOPA-induced dyskinesia. In these animals, striatal NG2-glia density was reduced with cells presenting activated phenotype while doxycycline antidyskinetic therapy promotes a return to NG2-glia cell density and protein to a not activated state.

摘要

NG2 胶质细胞会根据 L-DOPA 诱导的运动障碍改变其动态。在这些动物中，纹状体 NG2 胶质细胞密度降低，同时细胞表现出激活表型，而强力霉素抗运动障碍治疗则促进 NG2 胶质细胞密度和蛋白恢复到非激活状态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/546b/10084551/0277d7ce654a/10.1177_17590914231155976-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/546b/10084551/c28430da9c2d/10.1177_17590914231155976-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/546b/10084551/5948e811542f/10.1177_17590914231155976-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/546b/10084551/7c602ec36350/10.1177_17590914231155976-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/546b/10084551/33580c6f7866/10.1177_17590914231155976-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/546b/10084551/cbea6ff54bab/10.1177_17590914231155976-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/546b/10084551/0277d7ce654a/10.1177_17590914231155976-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/546b/10084551/c28430da9c2d/10.1177_17590914231155976-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/546b/10084551/5948e811542f/10.1177_17590914231155976-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/546b/10084551/7c602ec36350/10.1177_17590914231155976-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/546b/10084551/33580c6f7866/10.1177_17590914231155976-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/546b/10084551/cbea6ff54bab/10.1177_17590914231155976-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/546b/10084551/0277d7ce654a/10.1177_17590914231155976-fig6.jpg

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