Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, RI, USA.
Center for Gerontology and Healthcare Research, Brown University School of Public Health, Providence, RI, USA.
J Infect Dis. 2023 Aug 16;228(4):464-468. doi: 10.1093/infdis/jiad087.
In this national cohort of older adults residing long-term in US nursing homes between 2013 and 2017, we calculated period prevalence estimates for antibiotic prescribing, rates of prescribing, and days of therapy. Among 1 375 062 residents, 66.2% were prescribed at least 1 antibiotic during the nursing home stay. The most prevalent antibiotic classes were fluoroquinolones, sulfonamides and related agents, and first-generation cephalosporins. Levofloxacin, ciprofloxacin, and sulfamethoxazole-trimethoprim were the most prevalent antibiotics. These results can inform antibiotic stewardship interventions to reduce antibiotic overprescribing, improve appropriateness, and reduce related adverse outcomes in nursing homes.
在这项针对 2013 年至 2017 年期间长期居住在美国养老院的老年人群体的全国队列研究中，我们计算了抗生素处方的时期患病率估计、处方率和治疗天数。在 1375062 名居民中，66.2%的人在养老院期间至少开了一种抗生素。最常见的抗生素类别是氟喹诺酮类、磺胺类和相关药物以及第一代头孢菌素。左氧氟沙星、环丙沙星和复方磺胺甲噁唑是最常见的抗生素。这些结果可以为抗生素管理干预提供信息，以减少养老院中抗生素的过度处方、提高其适当性并减少相关不良后果。
