Division of Adolescent and Young Adult Medicine, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California, USA.
Biostatistics Core, Children's Hospital Los Angeles, Los Angeles, California, USA.
Pediatr Obes. 2023 Jul;18(7):e13032. doi: 10.1111/ijpo.13032. Epub 2023 Apr 5.
Multiple organizations have published guidelines for the screening and treatment of obesity and related comorbidities in youth, including the use of anti-obesity medications (AOM). This study aimed to determine which paediatric patients: (1) receive a diagnostic code for obesity; (2) are most likely to be screened for hyperlipidaemia, non-alcoholic fatty liver disease, and type 2 diabetes mellitus; and (3) are most likely to be prescribed AOM.
A cohort of 35 898 patients 9 years 4 months to 17 years 6 months of age with a BMI > 30 or greater than the 95th% on three separate outpatient encounters was generated using the TriNetX database. Logistic regression models were used to estimate the associations between demographics in the study population and the likelihood of diagnosis of obesity, screening for comorbidities, and prescription of AOMs.
Asian, Black, and Hispanic youths had increased odds of having a diagnosis of obesity and being screened for all three comorbidities. Documentation of obesity was associated with increased odds of screening for all comorbidities. Female sex, documentation of obesity, and higher BMIs were associated with increased odds of being prescribed AOMs. Black and Native American races decreased the likelihood of being prescribed AOM.
Management of obesity in terms of documentation of disease, screening for comorbidities, and initiation of AOM continues to fall short of the guidelines put forth by multiple organizations. Race/ethnicity, sex, and BMI correlate with differences in care provided to obese paediatric patients. Further research is needed to identify the barriers to and causes of these disparities.
多个组织已经发布了有关青少年肥胖和相关合并症的筛查和治疗指南,包括使用抗肥胖药物(AOM)。本研究旨在确定哪些儿科患者:(1)接受肥胖的诊断代码;(2)最有可能被筛查血脂异常、非酒精性脂肪性肝病和 2 型糖尿病;(3)最有可能被开 AOM。
使用 TriNetX 数据库生成了一组 35898 名年龄在 9 岁 4 个月至 17 岁 6 个月之间的 BMI>30 或三次单独门诊就诊中大于第 95%百分位数的患者队列。使用逻辑回归模型估计研究人群中的人口统计学特征与肥胖诊断、合并症筛查和 AOM 处方的可能性之间的关联。
亚洲、黑人和西班牙裔青少年肥胖诊断和三种合并症筛查的可能性增加。肥胖的记录与所有三种合并症筛查的可能性增加有关。女性、肥胖的记录和更高的 BMI 与服用 AOM 的可能性增加有关。黑人及美国原住民种族降低了服用 AOM 的可能性。
从疾病记录、合并症筛查和 AOM 开始的肥胖管理仍然不符合多个组织提出的指南。种族/民族、性别和 BMI 与肥胖儿科患者提供的护理差异相关。需要进一步研究以确定这些差异的障碍和原因。