抗-M 热反应性的实用评估
Practical evaluation of a warm-reactive anti-M.
机构信息
MD, PhD, Resident Physician, Department of Pathology and Laboratory Medicine, University of Wisconsin Hospital and Clinics, 600 Highland Avenue, Madison, WI 53792, US.
MLS(ASCP)CM, SBBCM, Senior Medical Technologist, Department of Pathology and Laboratory Medicine, University of Wisconsin Hospital and Clinics, Madison, WI, US.
出版信息
Immunohematology. 2023 Apr 5;39(1):15-18. doi: 10.21307/immunohematology-2023-004. Print 2023 Apr 1.
Anti-M is usually a naturally occurring antibody directed against M in the MNS blood group system. It does not require exposure to the antigen from previous transfusion or pregnancy. Anti-M is usually of the immunoglobulin M (IgM) isotype, binds best at about 4°C, binds well at room temperature, and rarely binds at 37°C. As a result of its lack of binding at 37°C, anti-M is usually clinically insignificant. There have been rare cases reported of an anti-M that reacts at 37°C. Such an exceptional anti-M may cause hemolytic transfusion reactions. We report a case of a warm-reactive anti-M and the investigational process used to identify it.
抗-M 通常是一种针对 MNS 血型系统中 M 的天然存在的抗体。它不需要暴露于先前输血或妊娠的抗原。抗-M 通常为免疫球蛋白 M（IgM）同种型，在约 4°C 时结合最佳，在室温下结合良好，很少在 37°C 时结合。由于其在 37°C 时结合不良，抗-M 通常在临床上意义不大。曾有报道称，罕见情况下抗-M 在 37°C 时发生反应。这种特殊的抗-M 可能会引起溶血性输血反应。我们报告了一例温反应性抗-M 及其鉴定过程。
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