Division of Cardiology, Massachusetts General Hospital, Boston MA.
Division of Sleep Medicine, Brigham and Women's Hospital, Boston MA.
Am Heart J. 2023 Jul;261:95-103. doi: 10.1016/j.ahj.2023.03.014. Epub 2023 Apr 3.
Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice and is associated with significant morbidity, mortality, and financial burden. Obstructive sleep apnea (OSA) is more common in individuals with AF and may impair the efficacy of rhythm control strategies including catheter ablation. However, the prevalence of undiagnosed OSA in all-comers with AF is unknown.
This pragmatic, phase IV prospective cohort study will test 250-300 consecutive ambulatory AF patients with all patterns of atrial fibrillation (paroxysmal, persistent, and long-term persistent) and no prior sleep testing for OSA using the WatchPAT system, a disposable home sleep test (HST). The primary outcome of the study is the prevalence of undiagnosed OSA in all-comers with atrial fibrillation.
Preliminary results from the initial pilot enrollment of approximately 15% (N = 38) of the planned sample size demonstrate a 79.0% prevalence of at least mild (AHI≥5) OSA or greater in consecutively enrolled patient with all patterns of AF.
We report the design, methodology, and preliminary results of our study to define the prevalence of OSA in AF patients. This study will help inform approaches to OSA screening in patients with AF for which there is currently little practical guidance.
NCT05155813.
心房颤动（AF）是临床实践中最常见的心律失常，与显著的发病率、死亡率和经济负担有关。阻塞性睡眠呼吸暂停（OSA）在 AF 患者中更为常见，并且可能会影响节律控制策略（包括导管消融）的疗效。然而，所有 AF 患者中未确诊的 OSA 的患病率尚不清楚。
这项实用的、四期前瞻性队列研究将使用 WatchPAT 系统（一种一次性家庭睡眠测试（HST））对 250-300 例连续的、有症状的 AF 患者（包括阵发性、持续性和长期持续性）进行测试，这些患者均无 OSA 的既往睡眠测试。研究的主要结局是所有 AF 患者中未确诊的 OSA 的患病率。
计划样本量的初始试点招募约 15%（N=38）的初步结果显示，所有 AF 模式的连续入组患者中至少有 79.0%存在至少轻度（AHI≥5）的 OSA 或更严重的 OSA。
我们报告了我们的研究设计、方法和初步结果，以确定 AF 患者中 OSA 的患病率。这项研究将有助于为目前几乎没有实际指导的 AF 患者的 OSA 筛查提供信息。
NCT05155813。
