纳武单抗和伊匹单抗联合确定性放射治疗局部晚期头颈部鳞状细胞癌的1期临床试验的现场毒性分析 - Suppr

In-Field Toxicity Analysis of a Phase 1 Clinical Trial of Nivolumab and Ipilimumab With Definitive Radiation Therapy in Locally Advanced Squamous Cell Carcinoma of the Head and Neck.

作者信息

Ali Ayesha S, Manukian Gregor, Johnson Jennifer M, Vathiotis Ioannis, Axelrod Rita, Keith Scott W, Curry Joseph, Cognetti David, Luginbuhl Adam, Argiris Athanassios, Bar-Ad Voichita

机构信息

Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania.

出版信息

Int J Radiat Oncol Biol Phys. 2023 Sep 1;117(1):181-185. doi: 10.1016/j.ijrobp.2023.03.065. Epub 2023 Apr 3.

DOI:10.1016/j.ijrobp.2023.03.065

PMID:37019367

Abstract

摘要

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In-Field Toxicity Analysis of a Phase 1 Clinical Trial of Nivolumab and Ipilimumab With Definitive Radiation Therapy in Locally Advanced Squamous Cell Carcinoma of the Head and Neck.纳武单抗和伊匹单抗联合确定性放射治疗局部晚期头颈部鳞状细胞癌的1期临床试验的现场毒性分析

Int J Radiat Oncol Biol Phys. 2023 Sep 1;117(1):181-185. doi: 10.1016/j.ijrobp.2023.03.065. Epub 2023 Apr 3.

Assessing Response for Nivolumab Plus Ipilimumab in Squamous Cell Carcinoma of the Head and Neck.

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Assessing Response for Nivolumab Plus Ipilimumab in Squamous Cell Carcinoma of the Head and Neck.

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Assessing Response for Nivolumab Plus Ipilimumab in Squamous Cell Carcinoma of the Head and Neck-Reply.

JAMA Oncol. 2024 Jan 1;10(1):144-145. doi: 10.1001/jamaoncol.2023.5407.

Phase III study of nivolumab alone or combined with ipilimumab as immunotherapy versus standard of care in resectable head and neck squamous cell carcinoma.纳武利尤单抗单药或联合伊匹单抗免疫治疗与可切除头颈部鳞状细胞癌标准治疗的 III 期研究。

Future Oncol. 2020 Dec;16(36):3035-3043. doi: 10.2217/fon-2020-0595. Epub 2020 Sep 9.

Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma.纳武利尤单抗联合伊匹单抗新辅助免疫治疗可诱导头颈部鳞状细胞癌患者发生主要病理缓解。

Nat Commun. 2021 Dec 22;12(1):7348. doi: 10.1038/s41467-021-26472-9.

Tumor microenvironmental modification by the current target therapy for head and neck squamous cell carcinoma.头颈部鳞状细胞癌的当前靶向治疗对肿瘤微环境的修饰。

J Exp Clin Cancer Res. 2023 May 5;42(1):114. doi: 10.1186/s13046-023-02691-4.

Neoadjuvant immunoradiotherapy results in high rate of complete pathological response and clinical to pathological downstaging in locally advanced head and neck squamous cell carcinoma.新辅助免疫放疗可使局部晚期头颈部鳞状细胞癌获得高完全病理缓解率和临床病理降期。

J Immunother Cancer. 2021 May;9(5). doi: 10.1136/jitc-2021-002485.

Nivolumab Combination Therapy in Advanced Esophageal Squamous-Cell Carcinoma.纳武利尤单抗联合治疗晚期食管鳞癌。

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Neoadjuvant nivolumab for patients with resectable HPV-positive and HPV-negative squamous cell carcinomas of the head and neck in the CheckMate 358 trial.CheckMate 358 试验中可切除的 HPV 阳性和 HPV 阴性头颈部鳞状细胞癌患者的新辅助纳武利尤单抗治疗。

J Immunother Cancer. 2021 Jun;9(6). doi: 10.1136/jitc-2021-002568.

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Nivolumab and ipilimumab in combination with radiotherapy in patients with high-risk locally advanced squamous cell carcinoma of the head and neck.纳武利尤单抗和伊匹单抗联合放疗用于治疗高危局部晚期头颈部鳞状细胞癌患者。

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A phase I/II trial of concurrent immunotherapy with chemoradiation in locally advanced larynx cancer.局部晚期喉癌同步免疫治疗联合放化疗的I/II期试验。

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In-Field Toxicity Analysis of a Phase 1 Clinical Trial of Nivolumab and Ipilimumab With Definitive Radiation Therapy in Locally Advanced Squamous Cell Carcinoma of the Head and Neck.

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