Ikeda Naoto, Imao Takeshi, Hisano Yuki, Kamao Takayuki, Uno Masatoshi, Mizushima Takaaki
Department of Internal Medicine, Kaneda Hospital.
Rinsho Ketsueki. 2023;64(3):230-232. doi: 10.11406/rinketsu.64.230.
A rare kind of malignant lymphoma, called primary effusion lymphoma (PEL) is associated with human herpesvirus 8 (HHV-8), and characterized by lymphomatous effusion in the bodily cavities. Although the initial clinical presentation of primary effusion lymphoma-like lymphoma (PEL-LL) is similar to that of PEL, PEL-LL is HHV-8 negative and has a favorable prognosis. A PEL-LL diagnosis was made after an 88-year-old man was admitted to our hospital with a pleural effusion. His disease regressed after effusion drainage. He demonstrated disease progression to diffuse large B-cell lymphoma after two years and ten months. Our example demonstrates that aggressive B-cell lymphoma can develop from PEL-LL.
一种罕见的恶性淋巴瘤，称为原发性渗出性淋巴瘤（PEL），与人类疱疹病毒8型（HHV-8）相关，其特征是体腔出现淋巴瘤性渗出液。虽然原发性渗出性淋巴瘤样淋巴瘤（PEL-LL）的初始临床表现与PEL相似，但PEL-LL为HHV-8阴性，预后良好。一名88岁男性因胸腔积液入院后被诊断为PEL-LL。胸腔积液引流后他的病情有所缓解。两年零十个月后，他的病情进展为弥漫性大B细胞淋巴瘤。我们的病例表明，侵袭性B细胞淋巴瘤可由PEL-LL发展而来。
