Department of Oral and Maxillofacial Surgery, Royal Brisbane and Women's Hospital, Bowen Bridge Road & Butterfield Street, Herston, Queensland, Australia.
Faculty of Medicine, University of Queensland, Level 2, Mayne Medical Building, 288 Herston Road, Herston, Queensland, Australia.
Head Neck. 2023 Jun;45(6):1503-1510. doi: 10.1002/hed.27363. Epub 2023 Apr 5.
Predictive nomograms are useful tools to guide clinicians in estimating disease course. Oral squamous cell carcinoma (OSCC) patients would benefit from an interactive prediction calculator that defines their levels of survival-risk specific to their tumors to guide the use of postoperative radiotherapy (PORT).
Patients with OSCC surgically treated with curative intent at four Head and Neck Cancer Centres were recruited retrospectively for development and validation of nomograms. Predictor variables include PORT, age, T and N classification, surgical margins, perineural invasion, and lymphovascular invasion. Outcomes were disease-free, disease-specific, and overall survivals over 5 years.
1296 patients with OSCC were in training cohort for nomogram analysis. Algorithms were developed to show relative benefit of PORT in survivals for higher-risk patients. External validation on 1212 patients found the nomogram to be robust with favorable discrimination and calibration.
The proposed calculator can assist clinicians and patients in the decision-making process for PORT.
预测列线图是一种有用的工具，可以帮助临床医生估计疾病的进程。口腔鳞状细胞癌（OSCC）患者将受益于一个交互式预测计算器，该计算器可以根据肿瘤为他们定义特定的生存风险水平，以指导术后放疗（PORT）的使用。
在四个头颈癌中心接受根治性手术治疗的 OSCC 患者被回顾性招募，用于列线图的开发和验证。预测变量包括 PORT、年龄、T 和 N 分类、手术切缘、神经周围侵犯和血管侵犯。结果是 5 年内无病、疾病特异性和总体生存率。
1296 例 OSCC 患者纳入列线图分析的训练队列。制定了算法来显示 PORT 在高风险患者生存中的相对获益。对 1212 例患者的外部验证发现，该列线图具有良好的判别力和校准度，非常稳健。
所提出的计算器可以帮助临床医生和患者在 PORT 的决策过程中做出决策。
