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抗精神病药物作为肺栓塞的一个促成因素:4例报告。

Antipsychotic drugs as a contributing factor of pulmonary embolism: A report of 4 cases.

作者信息

Maazouzi Mosaab, Bouallala Adnane, Haddadi Zakaria, Skiker Imane, Bazid Zakaria, Ismaili Nabila, El Ouafi Noha

机构信息

Faculty of Medicine and Pharmacy, Mohammed Ist University, Oujda, Morocco.

Department of Cardiology, Mohammed VI University Hospital Mohammed I University, Oujda, Morocco.

出版信息

Radiol Case Rep. 2023 Mar 22;18(5):1997-2000. doi: 10.1016/j.radcr.2023.02.046. eCollection 2023 May.

DOI:10.1016/j.radcr.2023.02.046
PMID:37020600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10068010/
Abstract

Pulmonary embolism is the third leading cause of cardiovascular death in the world after stroke and heart attack; several factors have been identified, and it has been reported that antipsychotic drugs increase the risk of pulmonary embolism. It is a brief communication reporting the case of 4 patients under antipsychotic drugs, were hospitalized in the intensive care unit of cardiology in Mohammed VI hospital center for the management of pulmonary embolism. All the etiological investigations performed including SARS COV2 viral serologies with PCR, tumor markers, chest-abdomen-pelvis CT angiogram scan, phthisiology, thrombophilia tests, and lower limbs echo Doppler returned without any notable findings, and the evolution was positive after anticoagulation and stopping antipsychotics.

摘要

肺栓塞是全球继中风和心脏病发作之后心血管死亡的第三大主要原因;已经确定了几个因素,并且有报道称抗精神病药物会增加肺栓塞的风险。这是一篇简短的通讯,报告了4例服用抗精神病药物的患者,他们在穆罕默德六世医院中心心脏病重症监护病房住院治疗肺栓塞。所有进行的病因学检查,包括SARS-CoV2病毒血清学PCR检测、肿瘤标志物、胸腹盆腔CT血管造影扫描、肺病学、血栓形成倾向检测以及下肢超声多普勒检查,均未发现任何显著异常,抗凝治疗并停用抗精神病药物后病情好转。

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本文引用的文献

1
Current antipsychotic agent use and risk of venous thromboembolism and pulmonary embolism: a systematic review and meta-analysis of observational studies.当前抗精神病药物的使用与静脉血栓栓塞和肺栓塞风险:观察性研究的系统评价和荟萃分析
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Pulmonary Embolism.肺栓塞。
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Venous thrombosis during olanzapine treatment: a complex association.奥氮平治疗期间的静脉血栓形成:一种复杂的关联。
Neth J Med. 2018 Aug;76(6):263-268.
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Antipsychotic drug exposure and risk of pulmonary embolism: a population-based, nested case-control study.抗精神病药物暴露与肺栓塞风险:一项基于人群的巢式病例对照研究。
BMC Psychiatry. 2015 Apr 29;15:92. doi: 10.1186/s12888-015-0479-9.
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